N(1)- ethyl- N- (11)- ((cyclopropyl)methyl)- 4,8- diazaundecane- 1,11- diamine

an inhibitor of spermidine-spermine-N(1)-acetyltransferase & antitumor agent against cultured human lung cancer cells; structure given in first source; RN refers to tetrahydrobromide compound

Also Known As:

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Casero, R A: 2 articles (02/2001 - 01/2000)
2.	Davidson, N E: 2 articles (02/2001 - 01/2000)
3.	Woster, P M: 2 articles (02/2001 - 01/2000)
4.	Fiuza, Sonia M: 1 article (02/2014)
5.	Marques, Maria P M: 1 article (02/2014)
6.	Oredsson, Stina: 1 article (02/2014)
7.	Persson, Lo: 1 article (02/2014)
8.	Silva, Tania M: 1 article (02/2014)
9.	Amendola, Roberto: 1 article (10/2010)
10.	Barba, Marco: 1 article (10/2010)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/01/1995 - "Exposure of hormone-dependent and -independent human breast cancer cells to 0.1-10 microM CPENSpm led to both growth inhibition and induction of programmed cell death. " 02/01/2014 - "In this study, the effects of the polyamine analogues N (1),N (11)-bis(ethyl)norspermine (BENSpm) and N (1)-cyclo-propylmethyl-N (11)-ethylnorspermine (CPENSpm) and the synthesized dinuclear complexes Pd2BENSpm (Pd-BENSpm), Pt2CPENSpm (Pt-CPENSpm) and Pd2Spm (Pd-Spm) were investigated in normal-like breast epithelial MCF-10A cells and the breast cancer cell lines JIMT-1 and L56BR-C1. " 02/01/2001 - "This study evaluates the ability of two polyamine analogues, N1-ethyl-N11-[(cyclopropyl)methyl]-4,8-diazaundecane (CPENSpm) and N1-ethyl-N11-[(cycloheptyl)methyl]-4,8-diazaundecane (CHENSpm) to synergize with cytotoxics in five human breast cancer cell lines. " 10/14/2010 - "Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2000 - "The unsymmetrically alkylated polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaunde-cane (CPENSpm) and N1-ethyl-N11-((cycloheptyl)methyl)-4,8-diazaundecane (CHENSpm) have been shown previously to have cytotoxic effects in breast and non-small cell lung cancer cells. " 01/01/1995 - "Each of the analogues N1-ethyl-N11-propargyl-4,8-diazaundecane (PENSpm), N1-ethyl-N11-(cyclobutyl)methyl-4,8-diazaundecane (CBENSpm), and N1-ethyl-N11-(cyclopropyl)methyl-4,8-diazaundecane (CPENSpm) is cytotoxic to a representative non-small-cell lung carcinoma line, NCI H157, while being only growth-inhibitory to a representative small-cell-lung carcinoma line, NCI H82. "
3.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/1995 - "Each of the analogues N1-ethyl-N11-propargyl-4,8-diazaundecane (PENSpm), N1-ethyl-N11-(cyclobutyl)methyl-4,8-diazaundecane (CBENSpm), and N1-ethyl-N11-(cyclopropyl)methyl-4,8-diazaundecane (CPENSpm) is cytotoxic to a representative non-small-cell lung carcinoma line, NCI H157, while being only growth-inhibitory to a representative small-cell-lung carcinoma line, NCI H82. "

Related Drugs and Biologics

1.	Polyamines
2.	N(1)- ethyl- N- (11)- ((cycloheptyl)methyl)- 4,8- diazaundecane
3.	N(1),N(11)-diethylnorspermine
4.	Spermine
5.	Hormones (Hormone)
6.	Polyamine Oxidase
7.	N(1)- ethyl- N(11)- (cyclobutyl)methyl- 4,8- diazaundecane- 1,11- diamine
8.	N(1)- ethyl- N(11)- propargyl- 4,8- diazaundecane- 1,11- diamine