I kappa B beta protein

NF-kappa B antagonist; amino acid sequence in first source; RefSeq NM_010908 (mouse), NM_001001716 (human), NM_030867 (rat)

Also Known As:

I-kappa-B-beta protein, rat; IKB beta protein; IKB-beta protein, mouse; IKBB protein, human; IkappaBbeta; NFKBIB protein, human; Nfkbib protein, mouse; Nfkbib protein, rat; TRIP9 protein, human; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta protein, mouse; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta protein, rat; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta protein, human; thyroid receptor interacting protein 9, human

Networked: 27 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - I-kappa B Proteins: 150
      - I kappa B beta protein: 27

Experts

1.	Baltimore, David: 1 article (08/2010)
2.	Ghosh, Sankar: 1 article (08/2010)
3.	Hayden, Mathew S: 1 article (08/2010)
4.	Hoffmann, Alexander: 1 article (08/2010)
5.	Long, Meixiao: 1 article (08/2010)
6.	Lynch, Candace: 1 article (08/2010)
7.	Oeckinghaus, Andrea: 1 article (08/2010)
8.	Rao, Ping: 1 article (08/2010)
9.	Scott, Martin L: 1 article (08/2010)
10.	West, A Philip: 1 article (08/2010)

Related Diseases

1.	Infections 06/01/2002 - "Our study reports that infection of cultured astrocytes with TMEV resulted in a time-dependent phosphorylation of IkappaBalpha, degradation of IkappaBalpha and IkappaBbeta, activation of NF-kappaB and expression of NOS-2. " 05/01/2004 - "Investigation of the mechanisms of NF-kappaB activation following HCMV infection showed a rapid and sustained decrease in the inhibitors of NF-kappaB, IkappaBalpha and IkappaBbeta. " 10/01/2001 - "Here we present evidence that ts1 infection of astrocytes in vitro activates NF-kappaB by enhanced proteolysis of the NF-kappaB inhibitors, IkappaBalpha and IkappaBbeta. " 07/27/2001 - "We employed a retroviral infection approach to stably express transdominant (TD) mutants of IkappaBalpha, IkappaBbeta, or IkappaBepsilon and dominant negative (dn) versions of IkappaB kinases (IKK) 1 or 2 as well as a constitutively active version of IKK2 in human endothelial cells. " 04/01/1999 - "Inhibition of IFN-beta expression directly correlated with a reduction in the binding of NF-kappaB (p50-RelA) complex to PRDII after Sendai virus infection in IkappaBalpha-expressing cells, whereas IFN-beta expression and NF-kappaB binding were only slightly reduced in IkappaBbeta-expressing cells. "
2.	HTLV-I Infections (HTLV-I Infection) 05/01/1996 - "Together, these studies suggest that Tax-mediated inactivation Of IkappaBbeta may play a role in the persistent nuclear expression of c-Rel induced by HTLV-I infection."
3.	Cerebral Hemorrhage 07/01/2006 - "The aim of this study was to examine the impact of intracerebral hemorrhage on cardiomyocyte contractile function, intracellular Ca2+ handling, Ca2+ cycling proteins, I kappa B beta protein (IkappaB) phosphorylation, hypoxia-inducible factor 1alpha (HIF-1alpha), and nitrosative damage within 48 hours of injury. "
4.	Hypoxia (Hypoxemia) 07/01/2006 - "The aim of this study was to examine the impact of intracerebral hemorrhage on cardiomyocyte contractile function, intracellular Ca2+ handling, Ca2+ cycling proteins, I kappa B beta protein (IkappaB) phosphorylation, hypoxia-inducible factor 1alpha (HIF-1alpha), and nitrosative damage within 48 hours of injury. "
5.	Necrosis 08/26/2010 - "IkappaBbeta degradation releases NF-kappaB dimers which upregulate pro-inflammatory target genes such as tumour necrosis factor-alpha (TNF-alpha). " 11/15/2006 - "However, the IkappaBbeta promoter was not substantially activated by pro-inflammatory cytokines, such as IL-1beta and tumour necrosis factor alpha, that are known to cause strong activation of NF-kappaB. " 04/01/2000 - "The effect correlates with the rapid degradation of IkappaBalpha, a sustained degradation of IkappaBbeta and increases in tumour necrosis factor alpha (TNF-alpha) and interleukin (IL) 6 production, two cytokines controlled by NF-kappaB. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	NF-KappaB Inhibitor alpha
3.	Proteins (Proteins, Gene)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Cytokines
6.	Secretory Leukocyte Peptidase Inhibitor
7.	Protein Isoforms (Isoforms)
8.	Paclitaxel (Taxol)
9.	Interferon-beta
10.	tax Gene Products (tax Gene Product)