adenylyl(3'-5')cytidine-3'-phosphate

12/01/2008 - "Treatment with 1 microM APCP, a competitive ecto-5'-NT/CD73 inhibitor, caused a significant reduction of 30% in glioma cell proliferation. "
09/01/2007 - "In addition, the cell treatment with APCP (alpha,beta-methyleneadenosine-5'-diphosphate), an ecto-5'-NT/CD73 inhibitor, led to a significant reduction in glioma cell proliferation. "
09/01/2013 - "We demonstrated that increased suppression of responder CD4(+) T-cell proliferation suppression was induced by CD4(+)CD39(+) T cells in the presence of CD73(+) glioma cells, which could be alleviated by the CD39 inhibitor ARL67156, the CD73 inhibitor APCP, or the adenosine receptor A2aR antagonist SCH58261. "
01/01/2012 - "The treatment of glioma cells with adenosine receptor antagonists, APCP (α,β-methylene ADP) and dipyridamole prevented the adenosine effect, indicating the participation of extracellular and intracellular signaling pathways in cell adhesion mediated by adenosine. "

01/01/2022 - "With the treatment of CD73 inhibitor APCP, the amount of CD8+ T cells and CD56+ NK cells infiltrated in tumors was elevated and the immunosuppressive effect of CD73 was eliminated. "
05/01/2019 - "Delivery of siRNA-CD73 or APCP reduced tumor size by 45 and 40%, respectively, when compared with control. "
02/01/2016 - "The CD73 inhibitor APCP significantly attenuated in vitro sphere formation and cell motility, as well as in vivo tumor growth observed for ALDHhigh cells. "
01/19/2016 - "Importantly, tumors treated with FK866 in combination with APCP contained a statistically significant lower proportion of Ki67 positive proliferating cells and a higher percentage of necrotic area. "
09/01/2012 - "In conclusion, we demonstrate that both T cells and B cells play a pivotal role in the APCP-induced anti-tumor immune response."

12/22/2022 - "Therefore, to fulfill the predictive task based on the historical observations with a different distribution, this paper proposes an improved transfer learning model combined with machine learning for APCP during COVID-19. "
12/22/2022 - "Most of the existing study on APCP is based on machine learning methods, which are not suitable for APCP during COVID-19 due to the different distribution of historical observations before and after the pandemic. "
12/22/2022 - "While many relevant issues have been widely studied, research into ambient air pollutant concentration prediction (APCP) during COVID-19 is still in its infancy. "

07/14/2023 - "Finally, the CD73 inhibitor APCP was administered to reduce inflammation and subcutaneous fibrosis. "
01/01/2014 - "Supporting a critical role of CD73 in isoflurane-mediated endothelial protection, a selective CD73 inhibitor (APCP) prevented isoflurane-induced protection against human endothelial cell inflammation and apoptosis. "
01/01/2022 - "Conversely, blockage of adenosine synthesis by CD73 inhibitor APCP or deficiency of A2A aggravated murine airway inflammation. "
01/01/2019 - "Here, we evaluated the effect of APCP in the development of inflammation in carrageenan-induced pleurisy model. "
01/01/2019 - "We found that treatment with APCP (400 µg/rat) significantly increased cell accumulation, exudate formation, and pro-inflammatory cytokine content into the pleural cavity in the acute phase (4 h) of inflammation, with no differences in the sub-acute phase (72 h) except for the regulation of monocyte chemotactic protein-1 levels. "

05/01/2013 - "This study examines the criterion-related validity and clinimetric properties of the Assessment of Preschool Children's Participation (APCP) for children with cerebral palsy (CP). "
08/01/2012 - "Data from a clinical trial involving 120 children with cerebral palsy indicated that the APCP has moderate to very good internal consistency. "