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bis(glutathionato)platinum(II)

a metabolite of cisplatin

Also Known As:

GS-platinum complex

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Glutathione: 14524
      - bis(glutathionato)platinum(II): 1
Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - bis(glutathionato)platinum(II): 1

Related Diseases

1.	Neoplasms (Cancer) 09/25/1993 - "Sci. 17, 463-468), is suggested to play a role in the elimination of the GS-platinum complex from tumor cells." 09/25/1993 - "Elimination of the GS-platinum complex from tumor cells may represent an important mechanism which reduces the intracellular accumulation of the platinum complex. "
2.	Leukemia L1210 09/25/1993 - "The GS-platinum complex was detected in L1210 leukemia cells incubated with 20 microM cisplatin. "
3.	Leukemia 09/25/1993 - "The GS-platinum was found to inhibit cell-free protein synthesis in a rabbit reticulocyte lysate system using both chloramphenicol acetyltransferase mRNA and poly(A) mRNA from HL-60 human promyelocytic leukemia cells (IC50 = 190 microM the GS-platinum complex). "

Related Drugs and Biologics

1.	Chloramphenicol O-Acetyltransferase (Chloramphenicol Acetyltransferase)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Platinum
5.	Cisplatin (Platino)