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ACEA 1011
a glycine site NMDA receptor antagonist; produces analgesia during the late phase of subcutaneous formalin injection in mice
Also Known As:
5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione; ACEA-1011
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinoxalines: 324
ACEA 1011: 4
Related Diseases
1.
Pain (Aches)
12/01/1995 - "
5-Chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione (ACEA-1011) has analgesic properties in animal models of tonic pain.
"
07/02/1993 - "
Similarly, blockade of the NMDA receptor allosteric site by the novel glycine site antagonist, ACEA-1011, also reduced the pain response in the late phase.
"
07/02/1993 - "
NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin.
"
2.
Myoclonus (Nocturnal Myoclonus)
03/06/1995 - "
The novel strychnine-insensitive glycine site antagonists ACEA-1011 (5-chloro-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline-2,3,-dio ne) and ACEA-1021 (5-nitro-6,7-dichloro-quinoxalinedione) significantly attenuated the myoclonus in cardiac-arrested rats.
"
3.
Ataxia (Dyssynergia)
03/05/1999 - "
The excitatory amino acid receptor antagonists, dizocilpine [(+)-MK-801; (5R,1OS)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten+ ++-5,10-imine], (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), LY 326325 [(-)-(3S,4aR,6R,8R)-6-[2-(1(2)H-tetrazol-5-yl)-ethyl]-dec ahydroisoquinaline-3-carboxylic acid], LY 300164 [7,8-methylenedioxy-1-(4-aminophenyl)-4-methyl-3-acetyl-4,5-dihydro-2,3- benzodiazepine], and ACEA 1011 (5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione) produced dose-dependent myorelaxation/ataxia in mice as determined using the horizontal wire assay.
"
Related Drugs and Biologics
1.
Dizocilpine Maleate (Dizocilpine)
2.
Glycine (Aminoacetic Acid)
3.
Glutamate Receptors (Glutamate Receptor)
4.
N-Methyl-D-Aspartate Receptors (NMDA Receptors)
5.
Strychnine
6.
Imines
7.
Formaldehyde (Formol)
8.
Benzodiazepines
9.
Analgesics (Analgesic Drugs)
10.
Acids