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cellular retinoic acid binding protein II

see also record for CRABP I

Also Known As:

retinoic acid binding protein II, cellular; CRABP II; CRABP-II; CRABP2 protein, human; Crabp2 protein, mouse; Crabp2 protein, rat; cellular retinoic acid binding protein 2, human; cellular retinoic acid binding protein 2, rat; cellular retinoic acid binding protein II, mouse

Networked: 58 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Retinoic Acid Receptors: 1114
      - cellular retinoic acid binding protein II: 58
  - Cytoplasmic and Nuclear Receptors: 3987
    - Retinoic Acid Receptors: 1114
      - cellular retinoic acid binding protein II: 58

Experts

1.	Li, Hong: 4 articles (04/2018 - 01/2012)
2.	Noy, Noa: 4 articles (05/2008 - 04/2002)
3.	Naito, Mikihiko: 3 articles (03/2022 - 04/2010)
4.	Xin, Wei: 3 articles (03/2022 - 06/2014)
5.	Yu, Shuiliang: 3 articles (03/2022 - 06/2014)
6.	Zhou, Lan: 3 articles (03/2022 - 06/2014)
7.	Chen, Nan-Nan: 3 articles (03/2015 - 01/2012)
8.	Chen, Xiao-Yan: 3 articles (03/2015 - 01/2012)
9.	Kong, Qing-You: 3 articles (03/2015 - 01/2012)
10.	Liu, Jia: 3 articles (03/2015 - 01/2012)

Related Diseases

1.	Neuroblastoma 08/15/2006 - "Our findings also suggest that CRABP-II may be a potential therapeutic target for neuroblastoma." 08/15/2006 - "Cellular retinoic acid-binding protein II is a direct transcriptional target of MycN in neuroblastoma." 07/01/2012 - "We have designed such a degradation-inducing molecule targeting cIAP1 and CRABP-II, which are involved in proliferation of several cancer cell lines and in neuroblastoma growth, respectively. " 12/10/2008 - "Previously we have shown that CRABP-II expression levels are also elevated in neuroblastoma and Wilms tumors. " 08/15/2006 - "In contrast, de novo MycN protein synthesis was increased in CRABP-II-expressing neuroblastoma cells, thereby suggesting an autoregulatory loop that might exacerbate the effects of MycN gene amplification and affect the clinical outcome. "
2.	Neoplasms (Cancer) 08/08/2017 - "In this study, we show that deletion of CRABP-II in PDAC cells by CRISPR/Cas9 does not affect cancer cell proliferation, but decreases cell migration and invasion. " 06/01/2014 - "CRABP-II staining was also observed and progressively increased from pancreatic intraepithelial neoplasia 1 to 3. In addition, when fine needle aspiration specimens were evaluated from patients with PDAC, CRABP-II was positive in 55.6% cases if cytology diagnosis was "atypia," and in 87.5% cases, if "malignancy." Our study suggests that CRABP-II is highly and specifically expressed in PDAC and is more commonly expressed in high-grade precursor cancerous lesions than in low-grade lesions. " 03/08/2022 - "The small compound SNIPER-11 treatment effectively induced CRABP-II protein degradation, induced apoptosis, and suppressed tumor growth. " 04/11/2018 - "The biological effects of RA on cancer cells are largely determined by the patterns of CRABP-II and FABP5 expression. " 03/20/2015 - "In conclusion, CRABP-II and FABP5 expression patterns are neither related to the tumor grades nor correlated with RA sensitivity. "
3.	Osteosarcoma (Osteogenic Sarcoma) 04/29/1994 - "In this study we have used reverse transcription (RT) and competitive polymerase chain reaction (cPCR) to investigate the effects of RA on CRABP-II expression levels in the human osteosarcoma cell line MG-63. " 04/29/1994 - "Thus, although 9-cis RA does not bind to CRABP-II, it induces CRABP-II expression more efficiently than at-RA in human osteosarcoma cells." 04/29/1994 - "Competitive PCR demonstrates that 9-cis retinoic acid induces cellular retinoic acid-binding protein-II more efficiently than all-trans retinoic acid in human osteosarcoma cells." 12/30/1992 - "In this study we have used a reverse transcription polymerase chain reaction (RT-PCR) to demonstrate that adult primary human osteoblasts and SaOS-2, a human osteosarcoma-derived cell line with osteoblastic properties, express cellular retinol-binding protein I (CRBP I), cellular retinoic acid-binding protein II (CRABP II), and very low levels of CRABP I. We also show that CRABP II is expressed in the adult liver, which does not express CRABP I. The results suggest that CRABP II is the important isoform in the adult bone as well as in the adult liver. "
4.	Adenocarcinoma 06/01/2014 - "CRABP-II is a highly sensitive and specific diagnostic molecular marker for pancreatic ductal adenocarcinoma in distinguishing from benign pancreatic conditions." 06/01/2014 - "In this study, we studied the expression patterns of CRABP-II in pancreatic ductal adenocarcinoma (PDAC) compared with those in normal pancreas, chronic pancreatitis, and precancerous lesions. " 08/08/2017 - "Our previous study shows that cellular retinoic acid binding protein II (CRABP-II) is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and pre-cancerous lesions, but not detected in normal pancreatic tissues. "
5.	Lipodystrophy 01/01/2007 - "Interestingly, the gene for CRABP-II is located on chromosome 1q21-23, which is a region that has been linked with disorders such as familial combined hyperlipidemia (FCHL), type 2 diabetes mellitus, and partial lipodystrophy, all of which are characterized by dyslipidemia. " 05/30/2003 - "In this study, we excluded mutations within the complete coding region and the promoter of LMNA and the CRABP II gene in HIV-1 infected patients with lipodystrophy and also any correlation of the nucleotide polymorphism at codon 566 in exon 10 of LMNA with metabolic abnormalities. " 02/01/2003 - "Cellular Retinoic Acid Binding Protein-II gene (CRABP-II) (GDB 134819) is located on chromosome 1q21-23 and this region has been linked with related disorders such as Familial Combined Hyperlipidemia (FCHL), type 2 Diabetes Mellitus, and Lipodystrophy. "

Related Drugs and Biologics

1.	cellular retinoic acid binding protein II
2.	Tretinoin (Retinoic Acid)
3.	Retinoids
4.	Carrier Proteins (Binding Protein)
5.	retinoic acid receptor beta
6.	Messenger RNA (mRNA)
7.	cellular retinoic acid binding protein I
8.	Proteins (Proteins, Gene)
9.	Cellular Retinol-Binding Proteins
10.	Calreticulin

Related Therapies and Procedures

1.	Therapeutics