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retinoic acid receptor alpha

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Also Known As:

RAR alpha; RAR alpha1; RAR alpha2; RARA protein, human; RARalpha1; RARalpha2; Rara protein, mouse; Rara protein, rat; retinoic acid receptor alpha1; retinoic acid receptor alpha2; retinoic acid receptor, alpha protein, human; retinoic acid receptor, alpha protein, mouse; retinoic acid receptor, alpha protein, rat

Networked: 771 relevant articles (41 outcomes, 47 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Pandolfi, P P: 15 articles (01/2007 - 01/2001)
2.	Ley, Timothy J: 9 articles (02/2011 - 06/2002)
3.	Waxman, Samuel: 8 articles (03/2009 - 02/2002)
4.	Kogan, Scott C: 7 articles (03/2013 - 02/2003)
5.	Chen, Zhu: 7 articles (02/2010 - 02/2002)
6.	Zelent, Arthur: 7 articles (03/2009 - 08/2002)
7.	Dong, Shuo: 7 articles (01/2008 - 04/2002)
8.	Le Beau, Michelle M: 5 articles (03/2013 - 04/2003)
9.	Grimwade, David: 5 articles (12/2009 - 02/2003)
10.	Chen, Sai-Juan: 5 articles (03/2008 - 02/2002)

Related Diseases

1.	Acute Promyelocytic Leukemia 08/01/1997 - "Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predict relapse in acute promyelocytic leukemia (APL) patients in hematologic complete remission (CR). " 03/01/1996 - "To determine objective indices for differentiation which can be used for judging complete remission, we treated 18 patients with acute promyelocytic leukemia, and performed sequential analysis of bone marrow, karyotype, RAR alpha gene rearrangement and PML-RAR alpha fusion gene transcript. " 02/15/1994 - "Fifty-one patients subsequently were found to have the PML/RAR-alpha gene rearrangement indicative of acute promyelocytic leukemia, and 44 of these patients achieved complete remission (86%; 95% Cl, 76% to 96%). " 12/15/1993 - "In this study, 9 patients (pts) with acute promyelocytic leukemia (APL) in long-term remission for 4 to 12 years were analyzed for the presence of MRD by RT-PCR amplification of the specific PML/RAR-alpha fusion gene. " 04/01/1997 - "Absence of detectable PML-RAR alpha fusion transcripts in long-term remission patients after BMT for acute promyelocytic leukemia."
2.	Leukemia 11/01/2015 - "The frequency and clinical significance of promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARA) mutational status using Sanger sequencing were evaluated. " 08/01/2015 - "The aim of this project was to validate earlier time frames for the Abbott Molecular Vysis LSI promyelocytic leukemia (PML)/ retinoic acid receptor alpha (RARA) fluorescence in situ hybridization (FISH) probe (ASR 6-16 h). " 01/01/2015 - "Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma." 11/13/2013 - "As an initial application of this system, the PML/RARA fusion gene sequence formed from promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) was successfully detected. " 10/01/2012 - "The t(15;17) results in the fusion of the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes. "
3.	Residual Neoplasm 01/01/1995 - "Disappearance of the PML/RAR alpha rearrangement after ATRA suggests that ATRA is effective against minimal residual disease." 11/01/2008 - "RQ-PCR, sensitive and reliable, can be used for monitoring the minimal residual disease in APL patients, however, its results should be interpreted carefully if it is used for detection of PML-RAR alpha fusion transcripts prospectively." 04/01/2003 - "These results indicate that qrtPCR monitoring of PML-RAR alpha NQ can identify patients at high risk of relapse and suggest that clinically practical PB NQ monitoring at more frequent FUP intervals may improve predictive accuracy for relapse or continuing CR in patients with persistent, fluctuating minimal residual disease levels." 05/01/2002 - "These results emphasize on the relevance of the correct identification of atypical PML-RAR(alpha) rearrangements because of the potential implications in leukemogenesis, in the response to treatment, and for the correct monitoring of minimal residual disease." 10/01/2000 - "Monitoring of minimal residual disease (MRD) was performed regularly by RT-PCR assay for PML-RAR alpha during consolidation. "
4.	Breast Neoplasms (Breast Cancer) 06/01/1998 - "In transient transfection studies in MCF-7 human breast cancer cells, pRAR2 and pRAR1 were E2-responsive; both of the RAR alpha 1 gene promoter inserts contained two GC-rich sites and bound Sp1 protein in gel mobility shift assays. " 10/01/1997 - "In this study, we evaluated the expression of RAR alpha, beta and gamma and CRBP type I (CRBP-I) gene expression in fibrocystic disease (FD) and in breast cancer (BC), studying 14 FD and 20 BC surgical samples by reverse transcription (RT)-PCR. " 10/01/2013 - "Retinoic acid receptor alpha was gained or amplified in 27% of HER2-positive and 13% of HER2-negative breast cancer samples. " 05/01/2013 - "Retinoic acid receptor alpha (RARα) selective compounds may guide the design of drugs that can be used in conjunction with hormonal adjuvant therapy in the treatment of breast cancer. " 10/01/2010 - "Retinoic acid receptor alpha (RARA) and other target sequences at 17p11.2 often represent the amplicons expressed in breast cancer, not in AML. "
5.	Neoplasms (Cancer) 02/01/2012 - "The bioassays indicated that compounds 1 and 2 could significantly inhibit the proliferation of cancer cell, and showed the agonist effect on the transactivity of retinoic acid receptor-alpha (RARalpha). " 06/24/2010 - "We hypothesized that specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer. " 03/01/2010 - "Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation." 11/01/2002 - "Both RAR-alpha and -gamma were also increased in high-grade cancer cells. " 08/01/1998 - "Compared with the heterogeneous localization of RAR alpha in cancer cells, there was widespread RAR alpha immunoreactivity in tumor-infiltrating lymphocytes, vascular endothelial cells, and stromal fibroblasts, underscoring the value of immunohistochemistry in the accurate determination of RAR/(RXR) content in tumor specimens."

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	retinoic acid receptor alpha
3.	arsenic trioxide (Trisenox)
4.	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
5.	Messenger RNA (mRNA)
6.	Retinoic Acid Receptors (Retinoic Acid Receptor)
7.	Proteins (Proteins, Gene)
8.	Protein Isoforms (Isoforms)
9.	A-Form DNA (A-DNA)
10.	Idarubicin (4 Demethoxydaunorubicin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
3.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
4.	Transplants (Transplant)
5.	Remission Induction