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connexin 26

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was SY to gap junction protein (NM); use connexins (NM) to search through 1993; RN given is for reduced rat clone Cx26-1/Cx26-2 connexin; in human, defective GJB2 are a cause of KERATODERMA, PALMOPLANTAR, Vohwinkel's syndrome (VS), autosomal dominant non-syndromic sensorineural deafness and keratitis-ichthyosis-deafness syndrome (KID syndrome); RefSeq NM_004004 (human), NM_008125 (mouse), ; GenBank AF304049 (Zebrafish)

Also Known As:

Cnx26 protein, mouse; Cx26 protein, Xenopus; Cx26 protein, human; Cx26 protein, mouse; Cx26 protein, rat; DFNA3 protein, human; DFNB1 protein, human; GJB2 protein, human; Gap junction beta-2 protein, human; Gap junction beta-2 protein, rat; Gjb-2 protein, mouse; Gjb2 protein, mouse; Gjb2 protein, rat; NSRD1 protein, human; beta2 connexin; connexin 26 protein, Xenopus; connexin 26 protein, mouse; connexin 26, rat; connexin 27.5 protein, zebrafish; connexin Cx26; connexin26 protein, human; connexin26, rat; cx27.5 protein, zebrafish; gap junction membrane channel protein beta 2, mouse; zfCx27.5 protein, zebrafish

Networked: 438 relevant articles (5 outcomes, 32 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Membrane Transport Proteins: 165
      - Connexins: 825
        connexin 26: 438

Experts

1.	Avraham, Karen B: 8 articles (09/2014 - 03/2002)
2.	Smith, Richard J H: 8 articles (08/2012 - 08/2002)
3.	Van Camp, Guy: 8 articles (05/2011 - 04/2003)
4.	Frei, Klemens: 7 articles (01/2015 - 07/2002)
5.	Ramsebner, Reinhard: 7 articles (01/2015 - 07/2002)
6.	Lucas, Trevor: 7 articles (01/2015 - 07/2002)
7.	Nojima, Hiroshi: 7 articles (03/2008 - 10/2004)
8.	Ikeda, Katsuhisa: 6 articles (07/2015 - 04/2002)
9.	Baumgartner, Wolf-Dieter: 6 articles (06/2013 - 07/2002)
10.	Nance, Walter E: 6 articles (05/2011 - 10/2002)

Related Diseases

1.	Hearing Loss (Hearing Impairment) 03/01/2014 - "ACEMg supplementation ameliorates progressive Connexin 26 hearing loss in a child." 01/01/2014 - "To study connexin 26 (Cx26) gene mutations among autosomal recessive non-syndromal hearing loss in Kuwaiti patients and evaluate their effect on phenotypes. " 09/01/2010 - "In a recent study, the authors have shown that a heterozygous missense mutation, p.R184Q, in the connexin 26 (Cx26) is causally related to hearing loss. " 01/01/2009 - "The aim of this study was to describe the clinical features of hearing loss due to mutations on connexin 26/30 coding genes (GJB2/GJB6). " 04/01/2008 - "This study aimed to assess mutations in GJB2 gene (connexin 26), as well as A1555G mitochondrial mutation in both the patients with profound genetic nonsyndromic hearing loss and healthy controls. "
2.	Deafness (Deaf Mutism) 11/01/2007 - "Mutations in the connexin 26 gene seem to be extremely common in non-syndromic hereditary deafness genesis, especially the 35delG, but there are still only a few studies that describe the audiometric characteristics of patients with these mutations. " 12/01/2005 - "Previous studies have shown that one of these genes, connexin 26 (GJB2), accounts for 30-60% of such deafness, but the relative contribution of the many other genes is not known, especially in the outbred UK population. " 08/01/2004 - "Our study conducted on 39 children with pre-lingual bilateral sensorineural autosomal recessive deafness showed as follows: (I) from a molecular perspective: an incidence of 41% in the cases studied of mutations in the encoding of the connexin 26 gene; a prevalence in our case study of the 35delG mutation (69%). " 09/01/2003 - "After taking into account other factors which are known to affect language development and speech perception in children with impaired hearing, no significant differences were found between the 15 children where connexin 26 was known to be the cause of deafness and the other 37 children in the study." 10/01/2001 - "[Study of a mutation in connexin 26 gene associated with congenital sensorineural deafness]."
3.	Neoplasms (Cancer) 10/01/2001 - "In the present study, we have evaluated the efficacy of the HSV-tk/GCV treatment in a panel of pancreatic tumor cells (NP-9, NP-18, NP-31) and the potentiation of the cytotoxic effect in combination with the overexpression of the connexin 26 gene (Cx26). " 01/01/2014 - "In contrast, enhanced GJC communication through the overexpression of wild-type connexin Cx26 increased tumor incidence. " 05/01/2010 - "Connexin 26 (Cx26), one of the gap junction-forming family members, is more controversial than other members, as a tumor suppressor. " 03/01/2008 - "Contrary to the previously purported role of gap junction (GJ) associated-protein connexin 26 (Cx26) as a tumor suppressor, increased expression of Cx26 has recently been demonstrated in several human malignancies. " 02/01/2008 - "Connexin 26 (Cx26) is one of the gap junction-forming family members classically considered to be tumor suppressors. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2006 - "Advanced cells within PC-3 and LNCaP prostate cancer progression models exhibit elevated connexin 26 (Cx26) levels-a trend validated in clinical samples. " 02/01/2004 - "Connexin 26 induces growth suppression, apoptosis and increased efficacy of doxorubicin in prostate cancer cells."
5.	Sensorineural Hearing Loss 04/01/2009 - "In a study of 530 individuals with non-syndromic, sensorineural hearing loss, we identified 18 mutations at connexin 26 (Cx26), four of which are novel (-23G>T, I33T, 377_383dupTCCGCAT, W172R) and the remaining 14 (ivs1+1G>A, M1V, 35delG, W24X, I35S, V37I, R75W, W77X, 312del14, E120del, Q124X, Y136X, R143W, R184P) being mutations previously described. " 11/01/2006 - "48 children with slight/mild sensorineural hearing loss and a matched group of 90 children with normal hearing participated in a genetic study investigating mutations in the GJB2 gene, coding for connexin 26, and the presence of the del(GJB6-D13S1830) and del(GJB6-D13S1854) deletions in the GJB6 gene, coding for connexin 30. " 11/01/2004 - "Several previous studies have demonstrated that mutations of connexin 26 (Cx26 or GJB2) are responsible for most cases of the recessive non-syndromic sensorineural hearing loss (NSSHL). " 09/01/2001 - "Connexin 26 studies in patients with sensorineural hearing loss." 01/01/2014 - "Mutation of the GJB2 gene, which encodes the connexin 26 (Cx26) gap junction (GJ) protein, is the most common cause of hereditary, sensorineural hearing loss. "

Related Drugs and Biologics

1.	human GJB3 protein
2.	Adenosine Triphosphatases (ATPase)
3.	12S ribosomal RNA
4.	Sodium-Potassium-Chloride Symporters
5.	Doxorubicin (Adriamycin)
6.	Connexins
7.	Proteins (Proteins, Gene)
8.	DNA (Deoxyribonucleic Acid)
9.	Aligeron (AS 2)
10.	Connexin 43 (Connexin43)

Related Therapies and Procedures

1.	Cochlear Implants (Cochlear Implant)
2.	Hearing Aids (Hearing Aid)
3.	Cochlear Implantation
4.	Individualized Medicine
5.	Intraperitoneal Injections