PD 145065

a non-selective endothelin(A)/endothelin(B) antagonist

Also Known As:

Ac-(5H-dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-Leu-Asp-Ile-Ile-Trp); PD-145065; PD145065; acetyl-(5H-dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan)

Networked: 11 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - PD 145065: 11

Experts

1.	Fandino, Javier: 1 article (02/2003)
2.	Rapoport, Robert M: 1 article (02/2003)
3.	Sherman, Jonathan D: 1 article (02/2003)
4.	Zuccarello, Mario: 1 article (02/2003)
5.	Bauerová, K: 1 article (01/2003)
6.	Doherty, A M: 1 article (01/2003)
7.	Drímal, D: 1 article (01/2003)
8.	Drímal, J: 1 article (01/2003)
9.	Kettmann, V: 1 article (01/2003)
10.	Knezl, V: 1 article (01/2003)

Related Diseases

1.	Ganglion Cysts (Ganglion) 11/01/1995 - "Here we have used the ETA receptor-selective antagonist, BQ-123, the ETB receptor-selective antagonist, BQ-788 and the ETA/ETB receptor non-selective antagonist, PD 145065, to study the role of these receptors in mediating the haemodynamic changes induced by an infusion of ET-1 to the anesthetized ganglion-blocked rat. " 01/01/1995 - "Here we have used the selective ETA receptor antagonist BQ-123, the selective ETB receptor antagonist BQ-788 and the nonselective ETA/ETB receptor antagonist PD 145065 to study the role of these receptors in mediating the hemodynamic changes induced by an infusion of ET-1 to the anesthetised, ganglion-blocked rat. "
2.	Hypoxia (Hypoxemia) 02/18/1997 - "Pretreatment with PD 145065 (a nonselective endothelin receptor blocker; 50 micrograms.kg-1.min-1) completely blocked this increase in pulmonary vascular resistance and blocked the increase in pulmonary vascular resistance in response to acute alveolar hypoxia after CPB (96.3 +/- 88.5% versus -9.7 +/- 16.4%; P < .05). " 07/01/1997 - "Perfusate hypoxia caused endothelium-dependent contraction in the arteries of all four groups that could be attenuated by NG-monomethyl-L-arginine (L-NMMA) or L-NMMA plus D-arginine, but not by L-NMMA plus L-arginine or endothelin receptor A and B antagonist PD 145065. "
3.	Myocardial Ischemia (Ischemic Heart Diseases) 12/01/1996 - "In rabbits subjected to myocardial ischemia and reperfusion, ET-1 infusion led to a higher incidence of ventricular arrhythmias, whereas ET-receptor antagonism with PD145065 significantly reduced ventricular arrhythmias. "
4.	Spasm (Spasms) 02/01/2003 - "Coinfusion of 100 microM cocaine with the endothelin receptor antagonist PD145065 (100 microM) prevented the spasm. "
5.	Pancreatitis 08/01/1997 - "We have previously shown that endothelin antagonism (PD145065) reduces the local severity of acute pancreatitis. "

Related Drugs and Biologics

1.	BQ 788
2.	cyclo(Trp-Asp-Pro-Val-Leu)
3.	Endothelin Receptor Antagonists
4.	Endothelin Receptors (Endothelin Receptor)
5.	Endothelins (Endothelin)
6.	omega-N-Methylarginine (NG Monomethyl L Arginine)
7.	Nitric Oxide Synthase (NO Synthase)
8.	Cocaine (Cocaine HCl)
9.	Arginine (L-Arginine)
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Intravenous Infusions