ethyl 4-isothiocyanatobutanoate

a potential anti-cancer drug; induces an immediate dose-dependent inhibitory action on the division of HeLa cells

Also Known As:

4-isothiocyanatobutanoic acid ethyl ester; E-4IB; E-4IB cpd; ethyl-4-isothiocyanatobutanoate

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bodo, J: 2 articles (01/2009 - 01/2005)
2.	Chovancova, J: 2 articles (01/2009 - 01/2005)
3.	Hunakova, L: 2 articles (01/2009 - 01/2005)
4.	Sedlak, J: 2 articles (01/2009 - 01/2005)
5.	Duraj, J: 1 article (01/2009)
6.	Jakubikova, J: 1 article (01/2009)
7.	Chalupa, Ivan: 1 article (11/2002)
8.	Horakova, Katarina: 1 article (11/2002)
9.	Horvathova, Mira: 1 article (11/2002)
10.	Kuricova, Miroslava: 1 article (11/2002)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2005 - "We conclude that E-4IB may be worth of further studies assessing its value in the ovarian carcinoma treatment, in combination with the other chemotherapeutic agents." 01/01/2005 - "Evaluation of the growth inhibitory effects of E-4IB in the human ovarian carcinoma cell line A2780 and its cisplatin-resistant variant A2780/CP using MTT-test and its apoptosis-inducing properties by flow cytometry was performed. " 01/01/2009 - "The aim of this study was to compare the effect of a new synthetic isothiocyanate derivative, ethyl 4-isothiocyanatobutanoate (E-4IB) and cisplatin (CDDP) in CDDP-sensitive human ovarian carcinoma cell line (A2780) and its resistant subline (A2780/CP). " 01/01/2005 - "Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate."
2.	Sarcoma (Soft Tissue Sarcoma) 06/01/1993 - "E-4IB produces a significant growth inhibition of transplanted sarcoma cells B77-RF in rats (at 28 mg/kg). "
3.	Neoplasms (Cancer) 06/01/1993 - "These findings support the presumption that E-4IB is a potential anti-cancer drug. "
4.	Fibrosarcoma 11/01/2002 - "Immunotoxic and cancerostatic effects of ethyl-4-isothiocyanatobutanoate in female Lewis rats with implanted fibrosarcoma."
5.	Body Weight (Weight, Body) 04/14/2000 - "The rats were administered intraperitoneally 12 times with E-4IB in three varying doses of 21, 28 and 35 mg/kg of body weight, over a period of 36 days. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	isothiocyanic acid