CD 832

a dihydropyridine calcium antagonist; structure given in first source

Also Known As:

2-(nicotinoylamino)ethyl 3-nitrooxypropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylate; CD-832

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - Nifedipine: 5733
        CD 832: 7
    - Nicotinic Acids: 13
      - Niacinamide: 2223
        CD 832: 7
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - Niacinamide: 2223
      - CD 832: 7

Related Diseases

1.	Stroke (Strokes) 07/23/1997 - "Protective effects of CD-832 on organ damage in stroke-prone spontaneously hypertensive rats."
2.	Angina Pectoris 08/01/1994 - "These results indicate that CD-832 potently relaxes venous smooth muscle, and that it may be a useful agent for the treatment of angina pectoris." 07/11/1996 - "This 'chrono-selective' cardiosuppressive effect of CD-832 could be of value in the treatment of cardiovascular diseases such as angina pectoris." 01/01/1998 - "Because the most evident side effects of calcium antagonists are caused by vasodilation and include headache and flushing, CD-832 may possibly be useful to treat subjects with hypertension or angina pectoris."
3.	Hypotension (Low Blood Pressure) 01/01/1998 - "These results suggest that CD-832 is a unique calcium antagonist which does not increase ICP during hypotension. " 07/23/1997 - "12-week repeated-administration of CD-832 and diltiazem led to a comparable hypotension and decreased heart rate. "
4.	Hypertension (High Blood Pressure) 07/23/1997 - "These results suggest that 12-week repeated-administration of CD-832 prevents the development of hypertension and the incidence of organ damage in SHRSPs. " 01/01/1998 - "Because the most evident side effects of calcium antagonists are caused by vasodilation and include headache and flushing, CD-832 may possibly be useful to treat subjects with hypertension or angina pectoris."
5.	Coronary Stenosis (Coronary Artery Stenosis) 09/01/1996 - "Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis." 09/01/1996 - "Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem. "

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	Calcium
3.	Diltiazem (Cardizem)
4.	Urea (Carbamide)
5.	Serotonin (5 Hydroxytryptamine)
6.	Nitrogen
7.	Isoproterenol (Isoprenaline)
8.	Histamine (Histamine Dihydrochloride)
9.	Creatinine
10.	4- chloro- 3',6'- dimethyl- 2,2'- iminodibenzoate (TO 115)

Related Therapies and Procedures

1.	Intravenous Infusions