notopterol

05/24/2023 - "Against this background, the present study evaluated the therapeutic efficacy and feasibility of notopterol (NOT), a furanocoumarin and principal component of Notopterygium incisum, in the modulation of ER stress and cancer stemness, and the subsequent effect on liver oncogenicity. "
10/11/2023 - "Notopterol, a furanocoumarin, has demonstrated anti-tumor effects in several types of tumors. "
01/01/2010 - "Among them, notopol (1), notopterol (2), 5-[(2 E,5 Z)-7-hydroxy-3,7-dimethyl-2,5-octadienoxy]psoralene (3), and 5-[(2,5)-epoxy-3-hydroxy-3,7-dimethyl-6-octenoxy]psoralene (4) showed significant antiproliferative activity against the HepG-2 and C6 cancer cell lines, with IC(50) values of 7.7-24.8 microg/mL (5-FU: ca. 5 microg/mL). "
05/24/2023 - "Furanocoumarin Notopterol: Inhibition of Hepatocellular Carcinogenesis through Suppression of Cancer Stemness Signaling and Induction of Oxidative Stress-Associated Cell Death."

05/01/2023 - "In this study, we found that notopterol inhibited growth and increased apoptosis of glioma via inhibiting STAT3 activity. "
05/01/2023 - "However, whether notopterol is beneficial to the treatment of glioma has not been reported. "
05/01/2023 - "Notopterol improves cognitive dysfunction and depression-like behavior via inhibiting STAT3/NF-ĸB pathway mediated inflammation in glioma-bearing mice."
05/01/2023 - "These results demonstrated that notopterol not only exerted anti-glioma effects via inhibiting STAT3 activity, but improved neuropsychiatric symptoms via inhibiting tumour associated inflammation through modulation of the STAT3/NF-kB pathway in glioma-bearing mice."
05/01/2023 - "In addition, notopterol treatment improved cognitive impairment and depression-like behavior in GL261 cell-based glioma mice via preventing the loss of dendritic spines and the reduction of synapse related proteins (PSD95 and Synapsin-1) in hippocampal neurons. "

07/01/2023 - "Notopterol inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf2/HO-1 signaling axis."
11/24/2020 - "The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis."
01/01/2020 - "The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis."
11/15/2023 - "Collectively, these results raise the possibility that notopterol relieves periodontal inflammation by suppressing and activating the NF-κB and PI3K/AKT/Nrf2 signaling pathways in periodontal tissue, respectively, suggesting its potential as an efficacious treatment therapy for periodontitis."
05/01/2023 - "Notopterol improves cognitive dysfunction and depression-like behavior via inhibiting STAT3/NF-ĸB pathway mediated inflammation in glioma-bearing mice."

05/01/2023 - "Notopterol improves cognitive dysfunction and depression-like behavior via inhibiting STAT3/NF-ĸB pathway mediated inflammation in glioma-bearing mice."
05/01/2023 - "In addition, notopterol treatment improved cognitive impairment and depression-like behavior in GL261 cell-based glioma mice via preventing the loss of dendritic spines and the reduction of synapse related proteins (PSD95 and Synapsin-1) in hippocampal neurons. "

02/27/2023 - "Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice."
02/27/2023 - "Whether notopterol has cardioprotective potential in hyperuricemia mice remains elusive. "