spinorphin

heptapeptide which is a potent inhibitor of enkephalin-degrading enzymes from the spinal cord or brain; does not show inhibitory activity toward enkephalin-degrading enzymes from kidney or blood; member of the opioid hemorphin family

Also Known As:

Leu-Val-Val-Tyr-Pro-Trp-Thr; leucyl--valyl-valyl-tyrosyl-prolyl-tryptophyl-threonine; L-Threonine, N-(N-(1-(N-(N-(N-L-leucyl-L-valyl)-L-valyl)-L-tyrosyl)-L-prolyl)-L-tryptophyl)-

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - spinorphin: 8

Experts

1.	Hazato, T: 2 articles (12/2002 - 12/2001)
2.	Ono, H: 2 articles (12/2002 - 12/2001)
3.	Yamamoto, Y: 2 articles (12/2002 - 12/2001)
4.	Fichna, Jakub: 1 article (12/2020)
5.	Kamysz, Elżbieta: 1 article (12/2020)
6.	Salaga, Maciej: 1 article (12/2020)
7.	Sobocińska, Małgorzata: 1 article (12/2020)
8.	Ayar, Ahmet: 1 article (01/2015)
9.	Kalkan, Omer Faruk: 1 article (01/2015)
10.	Kuzgun, Kemal Tuğrul: 1 article (01/2015)

Related Diseases

1.	Pain (Aches) 12/01/2002 - "The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed." 01/01/2015 - "Results from this study indicates that spinorphin significantly inhibits [Ca(2+)]i signaling, which are key for the modulation of cell membrane excitability and neurotransmitter release, preferably in nociceptive subtypes of this primary sensory neurons suggesting that peripheral site is involved in the pain modulating effect of this endogenous agent." 03/01/2003 - "Furthermore, DPP III activity correlated with APN activity, another spinorphin-degrading enzyme, in patients with pain (r = 0.444). " 12/01/2002 - "Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation."
2.	Hyperalgesia 12/01/2001 - "In the present study, the effects of leu-enkephalin and spinorphin on allodynia and mechanical and thermal nociceptions were examined in vivo using mice. " 12/01/2001 - "Naloxone antagonized both inhibitory effects of leu-enkephalin and spinorphin, suggesting that the endogenous opioidergic system can modulate allodynia. " 12/01/2001 - "Furthermore, spinorphin enhanced the inhibitory effect of enkephalin on allodynia induced by nociceptin. " 12/01/2001 - "Intrathecal (i.t.) administration of leu-enkephalin or spinorphin inhibited the allodynia induced by intrathecal nociceptin in a dose-dependent manner. "
3.	Inflammation (Inflammations) 12/01/2002 - "We also have reported roles for spinorphin in inflammation. " 12/01/2002 - "The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed." 12/01/2001 - "Recently, spinorphin was reported to block neutrophil activation induced by the chemotactic N-formylpeptide N-formylmethionylleucylphenylalanine (fMLF), suggesting a potential role as an endogenous negative regulator of inflammation. " 09/15/1997 - "These results suggest that spinorphin may be a new endogenous inflammation-regulatory peptide that modulates the interaction of FMLP with its receptor." 01/01/1998 - "Whether spinorphin, an endogenous regulator of enkephalin-degrading enzymes, plays a role in an anti-inflammatory action was examined, using a mouse air-pouch assay as a model of acute inflammation. "
4.	Colitis 12/10/2020 - "We investigated the in vivo heterodimer of Cys containing analogs of sialorphin and spinorphin (peptide X) in a mouse model of colitis. "

Related Drugs and Biologics

1.	Neurotransmitter Agents (Neurotransmitter)
2.	Leucine Enkephalin
3.	Enzymes
4.	Enkephalins
5.	Peptides (Polypeptides)
6.	CD13 Antigens (Alanine Aminopeptidase)
7.	Naloxone (Narcan)
8.	N-Formylmethionine Leucyl-Phenylalanine
9.	Indicators and Reagents (Reagents)
10.	Carrageenan

Related Therapies and Procedures

1.	Intravenous Administration