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F 0401
structure given in first source
Also Known As:
((+-)-(E)-3-(4-(1-imidazolyl)methylphenyl)-2-propen-1-yl)methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; F-0401
Networked:
1
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Dihydropyridines: 214
F 0401: 1
Related Diseases
1.
Ischemia
05/01/1994 - "
Pretreatment with F-0401 (1 and 10 mg/kg, i.p.) protected against neuronal damage to hippocampal CA1 pyramidal cells following 3 and 5 min of forebrain ischemia in the gerbil.
"
05/01/1994 - "
The protective effects of a novel dihydropyridine calcium antagonist with platelet-activating factor-antagonistic action, F-0401, on ischemic brain damage were investigated using experimental ischemia models in rats and gerbils.
"
2.
Brain Ischemia (Cerebral Ischemia)
05/01/1994 - "
Thus, this study shows that F-0401 prevents the occurrence of brain edema, disruption of blood-brain barrier and neuronal damage caused by cerebral ischemia.
"
3.
Brain Edema (Cerebral Edema)
05/01/1994 - "
Thus, this study shows that F-0401 prevents the occurrence of brain edema, disruption of blood-brain barrier and neuronal damage caused by cerebral ischemia.
"
4.
Stroke (Strokes)
05/01/1994 - "
The results demonstrate that F-0401 may be a powerful candidate as a therapeutic agent in the treatment of acute stroke in man.
"
5.
Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
05/01/1994 - "
F-0401 (1 and 10 mg/kg, i.p.) prevented increases in water content, determined by the wet-dry method, in ischemic areas 24 hr after 1 hr of middle cerebral artery occlusion in the rat.
"
Related Drugs and Biologics
1.
Platelet Activating Factor
2.
Calcium
3.
1,4-dihydropyridine (dihydropyridine)