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F 0401

structure given in first source

Also Known As:

((+-)-(E)-3-(4-(1-imidazolyl)methylphenyl)-2-propen-1-yl)methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; F-0401

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - F 0401: 1

Related Diseases

1.	Ischemia 05/01/1994 - "Pretreatment with F-0401 (1 and 10 mg/kg, i.p.) protected against neuronal damage to hippocampal CA1 pyramidal cells following 3 and 5 min of forebrain ischemia in the gerbil. " 05/01/1994 - "The protective effects of a novel dihydropyridine calcium antagonist with platelet-activating factor-antagonistic action, F-0401, on ischemic brain damage were investigated using experimental ischemia models in rats and gerbils. "
2.	Brain Ischemia (Cerebral Ischemia) 05/01/1994 - "Thus, this study shows that F-0401 prevents the occurrence of brain edema, disruption of blood-brain barrier and neuronal damage caused by cerebral ischemia. "
3.	Brain Edema (Cerebral Edema) 05/01/1994 - "Thus, this study shows that F-0401 prevents the occurrence of brain edema, disruption of blood-brain barrier and neuronal damage caused by cerebral ischemia. "
4.	Stroke (Strokes) 05/01/1994 - "The results demonstrate that F-0401 may be a powerful candidate as a therapeutic agent in the treatment of acute stroke in man."
5.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 05/01/1994 - "F-0401 (1 and 10 mg/kg, i.p.) prevented increases in water content, determined by the wet-dry method, in ischemic areas 24 hr after 1 hr of middle cerebral artery occlusion in the rat. "

Related Drugs and Biologics

1.	Platelet Activating Factor
2.	Calcium
3.	1,4-dihydropyridine (dihydropyridine)