arrestin3

may play a role in the regulation of G protein-coupled receptors; amino acid sequence given in first source; GenBank L14641

Also Known As:

ARR3 protein, human; ARRX protein, human; Arr3 protein, rat; X arrestin; X-arrestin; X-arrestin, rat; arrestin 3, retinal, human; arrestin 3, retinal, rat

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chaudhary, Preeti Kumari: 1 article (10/2021)
2.	Kim, Sanggu: 1 article (10/2021)
3.	Kim, Soochong: 1 article (10/2021)
4.	Challiss, R A John: 1 article (08/2015)
5.	Nash, Craig A: 1 article (08/2015)
6.	Nelson, Carl P: 1 article (08/2015)
7.	Rainbow, Richard D: 1 article (08/2015)
8.	Willets, Jonathon M: 1 article (08/2015)
9.	Benovic, Jeffrey L: 1 article (12/2011)
10.	Liu, Chengbao: 1 article (12/2011)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/01/2011 - "Overall, these studies demonstrate that arrestin2 levels decrease while arrestin3 levels increase during breast cancer progression and these changes correlate with a poor clinical outcome." 12/01/2011 - "Arrestin3 was also an independent prognostic marker of breast cancer with a hazard ratio of 1.65. " 12/01/2011 - "In contrast, arrestin3 expression significantly increased during breast cancer progression (P < 0.001) and increased expression was associated with decreased survival (P = 0.014). " 12/01/2011 - "Examination of the expression of the two nonvisual arrestins, arrestin2 and 3, in various breast cancer cell lines revealed comparable expression of arrestin3 in basal and luminal lines while arrestin2 expression was much higher in the luminal lines compared to the more aggressive basal lines. "
2.	Thrombosis (Thrombus) 10/15/2021 - "In conclusion, arrestin3, not arrestin2, plays a central role in the regulation of platelet functional responses and thrombus formation through general GPCR desensitization in platelets." 10/15/2021 - "Finally, we found that arrestin3 is critical for thrombus formation in vivo. "
3.	Retinoblastoma (Glioblastoma, Retinal) 09/15/2004 - "Expression of X-arrestin was detected at a low level in the Y79 retinoblastoma cell line but not in the WERI retinoblastoma cell line. " 09/15/2004 - "In order to delineate the promoter structure necessary for the pan-cone-specific expression of X-arrestin, the expression of the gene in retinoblastoma cell lines was investigated, and a structure-function analysis of the promoter was conducted in the appropriate cellular substrate. "
4.	Neuroblastoma 12/01/2004 - "In NS20Y neuroblastoma cells expressing an enhanced green-fluorescent protein-tagged D2 receptor (D2-EGFP), 2-h D2 agonist stimulation enhanced the colocalization of D2-EGFP with endogenous arrestin2 and arrestin3. "
5.	Hypertension (High Blood Pressure) 08/01/2015 - "Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension."

Related Drugs and Biologics

1.	Arrestins
2.	Vasoconstrictor Agents
3.	Phenobarbital (Luminal)
4.	enhanced green fluorescent protein