lactoferricin B

amino acid sequence given in first source

Also Known As:

lactoferricin; L-Phenylalanine, L-phenylalanyl-L-lysyl-L-cysteinyl-L-arginyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-tryptophyl-L-arginyl-L-methionyl-L-lysyl-L-lysyl-L-leucylglycyl-L-alanyl-L-prolyl-L-seryl-L-isoleucyl-L-threonyl-L-cysteinyl-L-valyl-L-arginyl-L-arginyl-L-alanyl-

Networked: 85 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hoskin, David W: 9 articles (01/2022 - 04/2005)
2.	Jenssen, Håvard: 5 articles (01/2020 - 05/2003)
3.	Riedl, Sabrina: 5 articles (01/2020 - 10/2014)
4.	Rinner, Beate: 5 articles (01/2020 - 10/2014)
5.	Zweytick, Dagmar: 5 articles (01/2020 - 10/2014)
6.	Lohner, Karl: 4 articles (01/2019 - 10/2014)
7.	Mader, Jamie S: 4 articles (06/2010 - 04/2005)
8.	Fierro-Medina, Ricardo: 3 articles (06/2020 - 07/2019)
9.	Leber, Regina: 3 articles (01/2020 - 11/2015)
10.	García Castañeda, Javier Eduardo: 3 articles (07/2019 - 03/2017)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2002 - "In this study the antitumor activities exerted by LFB, LfcinB and murine lactoferricin (LfcinM) on murine tumor cell lines and experimental tumors were investigated. " 01/01/2019 - "The bovine lactoferricin could be delivered to the tumor site by nanoparticles, be immediately released from nanoparticles in the acidic environment of lysosomes and the thermal condition caused by microwave radiation, and ultimately induce tumor apoptosis with the release of damage-associated molecular patterns (DAMPs). " 01/01/2020 - "In previous studies we showed that human lactoferricin (hLFcin) derived peptides facilitate specific killing of cancer cells. " 01/01/2022 - "Lactoferricin peptide (LP) has been reported to control cancer cell proliferation. " 10/30/2009 - "Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide with potent cytotoxic activity against cancer cells. "
2.	Infections 03/01/2012 - "Lactoferricin however showed promising results as a therapeutic agent and delayed both disease onset by 3days as well as reducing the viral load almost 15-fold when given as a single dose 24h post-infection. " 01/01/2014 - "Investigation of anti-infection mechanism of lactoferricin and splunc-1." 03/01/2012 - "When admixed with virus prior to inoculation, lactoferricin inhibited disease development and significantly reduced the viral load in a genital model of HSV-2 infection in mice. " 05/01/2004 - "The addition of non-cytotoxic and non-bactericidal concentrations of lactoferricin to cell monolayers before infection, under different bacterial growth experimental conditions, was ineffective or resulted in about a 10-fold increase in bacterial adhesion, whereas, in bacteria grown in conditions allowing maximal inv gene expression, a 10-fold inhibition of cell invasion by lactoferricin was observed. " 02/01/2004 - "Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages."
3.	Melanoma (Melanoma, Malignant) 01/01/2020 - "Design of human lactoferricin derived antitumor peptides-activity and specificity against malignant melanoma in 2D and 3D model studies." 01/01/2019 - "R-DIM-P-LF11-322 and DIM-LF11-318, derived from the cationic human host defense peptide lactoferricin show antitumor activity against human melanoma. " 09/22/2017 - "In vitro and in vivo cytotoxic activity of human lactoferricin derived antitumor peptide R-DIM-P-LF11-334 on human malignant melanoma." 10/01/2014 - "Killing of melanoma cells and their metastases by human lactoferricin derivatives requires interaction with the cancer marker phosphatidylserine." 11/01/2015 - "In this study we report on characteristic features of human lactoferricin (hLFcin) derivatives which facilitate specific killing of cancer cells of melanoma, glioblastoma and rhabdomyosarcoma compared with non-specific derivatives and the synthetic peptide RW-AH. "
4.	Squamous Cell Carcinoma of Head and Neck 07/01/2018 - "This study is to investigate the programmed death-ligand 1 (PD-L1) expression in HNSCC, and test the effect of lactoferricin B (LfcinB) on chemoresistance and its mechanism. " 07/01/2018 - "Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD-L1." 01/01/2017 - "A tetrameric peptide derived from bovine lactoferricin as a potential therapeutic tool for oral squamous cell carcinoma: A preclinical model." 01/01/2015 - "Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. " 01/01/2015 - "A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines."
5.	Bovine Mastitis 11/28/2017 - "The objective of the study was to clone bovine lactoferricin (LFcinB) gene into PiggyBac Transposon vector, expression study in the bovine mammary epithelial stem cells (bMESCs) and also to determine the antimicrobial property of recombinant LFcinB against bovine mastitis-causing organisms. " 11/28/2017 - "A PiggyBac mediated approach for lactoferricin gene transfer in bovine mammary epithelial stem cells for management of bovine mastitis." 11/01/2007 - "As a step toward prevention of bovine mastitis, a plasmid-mediated gene transfer technique was used to enable mammary cells to synthesize and secrete bovine lactoferricin and bovine tracheal antibacterial peptides. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Lactoferrin
3.	Dendrimers (Dendrons)
4.	poly(propyleneimine)
5.	Suspensions
6.	LTX-315
7.	Antimicrobial Cationic Peptides
8.	Antimicrobial Peptides
9.	Anti-Bacterial Agents (Antibiotics)
10.	lactoferrampin

Related Therapies and Procedures

1.	Oral Administration
2.	Intravenous Administration
3.	Therapeutics
4.	Intravenous Injections
5.	Immunotherapy