heat-shock protein 70.1

shares sequence identity with members of the eukaryotic heat-shock proteins; functions as a molecular chaperone; from Leishmania tropica; hsp70.1 & hsp 70.3 encode identical proteins which protect cells & facilitate their recovery from stress-induced damage; amino acid sequence given in first source; RefSeq NM_010478.2 (mouse)

Also Known As:

Networked: 65 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamashima, Tetsumori: 10 articles (01/2021 - 12/2009)
2.	Zhu, Hong: 3 articles (10/2014 - 02/2012)
3.	Oikawa, Shinji: 3 articles (06/2014 - 12/2009)
4.	Seo, Jeong-Sun: 3 articles (11/2008 - 01/2005)
5.	Seo, J S: 3 articles (12/2001 - 06/2001)
6.	Ni, Wei: 2 articles (01/2022 - 01/2022)
7.	Pei, Qing: 2 articles (01/2022 - 01/2022)
8.	Yao, Min: 2 articles (01/2022 - 01/2022)
9.	Yoshimoto, Tanihiro: 2 articles (10/2014 - 02/2012)
10.	Dazortsava, Maryia: 2 articles (06/2014 - 02/2012)

Related Diseases

1.	Neoplasms (Cancer) 03/05/2015 - "Using the Hsp70.1/3(-/-)(Hsp70(-/-)) mouse model, we observed that tumor-derived HSP70 was neither required for cellular transformation nor for in vivo tumor growth. " 12/01/2001 - "Here we show that injection of rat hsp70.1 into mouse tumors in situ causes the complete eradication of tumors, and generates potent systemic antitumor immunity mediated by CD4+ and CD8+ T cells. " 12/01/2001 - "Induction of systemic antitumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situ." 12/01/2001 - "Unexpectedly, simultaneous gene transfer of hsp70.1 and B7.1 compromised the efficacy of hsp-mediated tumor rejection--a problem which could be partially overcome by the timed delivery of hsp70.1 and B7.1. Thus, gene transfer of hsp70 into tumors can be employed to generate potent systemic antitumor immunity, but further consideration is required if this approach is to be successfully combined with immunotherapies employing other T-cell costimulators." 04/15/2012 - "Immunoprecipitation and Western blot analyses of individual samples confirmed significantly greater carbonylation of serotransferrin, heat shock protein 70-kDa protein 1 (HSP70.1), and α1-antitrypsin (A1AT) in tumor tissues compared to normal tissues. "
2.	Infarction (Infarctions) 08/01/2003 - "We conclude that inducible HSP70.1 and HSP70.3 are required for late-phase protection against infarction following IP in mice." 10/01/2010 - "After I/R, the Hsp70.1/70.3 double knockout and the Hsp70.1 single knockout had significantly increased and reduced infarct size, respectively. " 08/01/2003 - "Absence of inducible HSP70.1 and HSP70.3 had no effect, however, on classical or early-phase protection produced by IP, which significantly reduced infarct size in HSP70.1/3(-/-) mice. " 08/01/2003 - "In contrast, IP did not reduce infarct size in HSP70.1/3(-/-) mice. " 12/01/2001 - "The mean infarction volume was significantly larger in hsp70.1 knockout mice (92.5+/-8.3 mm(3)) than in the wild-type mice (59.3+/-8.9 mm,(3) P<0.001). "
3.	Retinal Degeneration 06/01/2001 - "The effect of oxygen on retinal degeneration in wild-type and hsp70.1 knockout neonatal retinal degeneration mice." 12/01/2001 - "The purposes of this study are to elucidate the retinal changes of heat shock protein 70.1 (hsp70.1) knockout mice and to compare them between in normal and in retinal degeneration (rd) mice. " 06/01/2001 - "The present study examined the effect of oxygen on photoreceptor degeneration in the retina of heat shock protein 70.1 (hsp70.1) knockout type and wild-type retinal degeneration (rd) mice. "
4.	Ischemia 02/01/2012 - "We propose that the cascades underlying lysosomal stabilization and regulating NF-κB activation by Hsp70.1 may influence neuronal survival/death after the ischemia/reperfusion." 09/01/2004 - "hsp70.1 KO and WT mice underwent focal ischemia for 120 minutes. " 01/01/2013 - "Hsp70.1 KO and wild-type mice were divided into sham control (Sham), exercise preconditioning (Ex), renal ischemia-after-exercise (Ex+IR), and ischemia (IR) groups. " 02/01/2012 - "Recently, we found that calpain-mediated cleavage of carbonylated Hsp70.1 in the hippocampal cornu Ammonis1 (CA1) contributes to neuronal death after transient global ischemia. " 03/19/2010 - "Here, we studied the molecular interaction between activated mu-calpain and the lysosomal Hsp70.1 in the monkey hippocampal CA1 neurons after the ischemia-reperfusion insult. "
5.	Sepsis (Septicemia) 01/01/2022 - "Additionally, knockdown of KANK2 in epithelial cells and deletion of hsp70.1 gene in CLP mice aggravated apoptosis and tissue damage, suggesting that interaction of KANK2 and HSP70 is critical for protecting lung injury induced by sepsis. " 05/01/2006 - "Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis." 01/01/2022 - "Hsp70.1 knockout and wildtype mice were used for creating sepsis model by cecal ligation and puncture (CLP). " 05/01/2006 - "NF-kappaB activation in lung tissue was increased in HSP70.1/3((-/-)) mice at all time points after sepsis initiation. " 05/01/2006 - "To address this question, we induced sepsis in HSP70.1/3 KO and HSP70.1/3 WT mice via cecal ligation and puncture (CLP). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Heat-Shock Proteins (Heat-Shock Protein)
3.	Transferrin (beta 2 Transferrin)
4.	heat-shock protein 70.1
5.	Retinaldehyde (Retinal)
6.	Molecular Chaperones (Chaperone, Molecular)
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	NF-kappa B (NF-kB)
9.	Cytokines
10.	Oxygen (Dioxygen)

Related Therapies and Procedures

1.	Immunotherapy
2.	Punctures
3.	Ligation