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gamma dendrotoxin

from the venom of green mamba, Dendroaspis angusticeps

Also Known As:

dendrotoxin, gamma; gamma-dendrotoxin

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - gamma dendrotoxin: 3

Experts

1.	Bagetta, Giacinto: 1 article (03/2004)
2.	Corasaniti, M Tiziana: 1 article (03/2004)
3.	Del Duca, Claudio: 1 article (03/2004)
4.	Dolly, J Oliver: 1 article (03/2004)
5.	Morrone, A Luigi: 1 article (03/2004)
6.	Nappi, Guiseppe: 1 article (03/2004)
7.	Palma, Ernesto: 1 article (03/2004)
8.	Piccirilli, Silvia: 1 article (03/2004)
9.	Benishin, C: 1 article (09/2003)
10.	Inglis, V: 1 article (09/2003)

Related Diseases

1.	Seizures (Absence Seizure) 03/01/2004 - "Systematic intraperitoneal administration of CGP040116 (5mg/kg given 30 min. previously) delayed the onset of EEG seizures and reduced the number of epileptogenic discharges typically observed in rats receiving an injection of gamma-dendrotoxin (35 pmol) alone. " 03/01/2004 - "In conclusion, the present data suggest that an excitotoxic, glutamate-mediated, type of mechanism underlies seizures and hippocampal damage induced by gamma-dendrotoxin in rats."
2.	Neuroblastoma 09/19/2003 - "In N1E 115 neuroblastoma cells, gamma-dendrotoxin (DTX, 200 nM) blocked the outward K(+) current by 31.1 +/- 3.5% (n = 4) with approximately 500 nM Ca(2+) in the pipet solution, but had no effect on the outward K(+) current when internal Ca(2+) was reduced. " 09/19/2003 - "Gamma-dendrotoxin blocks large conductance Ca2+-activated K+ channels in neuroblastoma cells."
3.	Fatigue 03/01/1999 - "Despite the approximately 55% higher value for initial force in the presence vs. absence of gamma-dendrotoxin, the rate at which fatigue occurred was not accelerated by the toxin, as assessed by the amount of time over which force declined by 25 and 50%. "

Related Drugs and Biologics

1.	Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)
2.	Glutamic Acid (Glutamate)
3.	Solutions