6- (6- (4- hydroxypiperidinyl)hexyloxy)- 3- methylflavone hydrochloride

a potent, selective & orally active sigma site ligand; has no effect on dopamine turnover; structure fiven in first source

Also Known As:

NPC 16377; NPC-16377; 4H-1-Benzopyran-4-one, 6-((6-(4-hydroxy-1-piperidinyl)hexyl)oxy)-3-methyl-2-phenyl-, hydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Ischemia 05/01/1993 - "In a model of global ischemia using conscious gerbils, NPC 16377 prevented damage to hippocampal CA1 neurons after either intraperitoneal or oral administration. " 05/01/1992 - "Compound 44 (6-[[6-(4-hydroxypiperidyl)hexyl]oxy]-3-methylflavone, NPC 16377) was systemically effective (ip and po) in two behavioral models predictive of antipsychotic compounds and systemically active in animal models of ischemia."
2.	Catalepsy 05/01/1993 - "NPC 16377 did not induce catalepsy in mice, suggesting a decreased liability for producing extrapyramidal side effects. "

1.	Antipsychotic Agents (Antipsychotics)

1.	Oral Administration