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SC 41661A
potential lipoxygenase inhibitor
Also Known As:
SC-41661A; SC41661A; 3-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)thiol-N- methyl-N-((2-pyridinyl)propanamide) hydrochloride
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
SC 41661A: 4
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
SC 41661A: 4
Experts
1.
Anderson, K M
: 1 article (05/2001)
2.
Bonomi, P
: 1 article (05/2001)
3.
Harris, J E
: 1 article (05/2001)
4.
Jadko, S
: 1 article (05/2001)
5.
Jao, W
: 1 article (05/2001)
6.
Ou, D
: 1 article (05/2001)
Related Diseases
1.
BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/01/1994 - "
Morphologic changes of apoptosis induced in human chronic myelogenous leukemia "blast" cells by SC41661A (Searle), a selective inhibitor of 5-lipoxygenase.
"
01/01/1994 - "
Cells were cultured from patients with chronic myelogenous leukemia in "blast" crisis with the selective inhibitor of 5-lipoxygenase, SC41661A[3-(3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)hiol]-N-me thyl-N-[2-(2- phridinyl-propanamide)].
"
04/01/1993 - "
We cultured chronic myelogenous leukemia cells from the peripheral blood of several patients in blast crisis with three inhibitors of lipoxygenases: ETYA, and the more selective A63162 (Abbott) or SC41661A (Searle).
"
2.
Blast Crisis (Blast Phase)
01/01/1994 - "
Cells were cultured from patients with chronic myelogenous leukemia in "blast" crisis with the selective inhibitor of 5-lipoxygenase, SC41661A[3-(3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)hiol]-N-me thyl-N-[2-(2- phridinyl-propanamide)].
"
04/01/1993 - "
We cultured chronic myelogenous leukemia cells from the peripheral blood of several patients in blast crisis with three inhibitors of lipoxygenases: ETYA, and the more selective A63162 (Abbott) or SC41661A (Searle).
"
3.
Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
04/01/1993 - "
Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase.
"
4.
Pancreatic Neoplasms (Pancreatic Cancer)
03/01/1998 - "
The 5-lipoxygenase inhibitors ETYA, SC41661A and MK886 reduced the proliferation and viability of Panc-1 human pancreatic cancer cells.
"
5.
Lung Neoplasms (Lung Cancer)
05/26/2001 - "
The 5-lipoxygenase inhibitors SC41661A and MK886 with different mechanisms of action and the free radical spin trap, NTBN inhibit proliferation of the human bronchiolar lung cancer cell line NCI H-358 (5807 CRL).
"
Related Drugs and Biologics
1.
Lipoxygenase Inhibitors
2.
5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
3.
Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
4.
MK-886
5.
Lipoxygenases
6.
Free Radicals
7.
N- hydroxy- N- (1- (4- (phenylmethoxy)phenyl)ethyl)- acetamide