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SC 41661A

potential lipoxygenase inhibitor

Also Known As:

SC-41661A; SC41661A; 3-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)thiol-N- methyl-N-((2-pyridinyl)propanamide) hydrochloride

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Anderson, K M: 1 article (05/2001)
2.	Bonomi, P: 1 article (05/2001)
3.	Harris, J E: 1 article (05/2001)
4.	Jadko, S: 1 article (05/2001)
5.	Jao, W: 1 article (05/2001)
6.	Ou, D: 1 article (05/2001)

Related Diseases

1.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/1994 - "Morphologic changes of apoptosis induced in human chronic myelogenous leukemia "blast" cells by SC41661A (Searle), a selective inhibitor of 5-lipoxygenase." 01/01/1994 - "Cells were cultured from patients with chronic myelogenous leukemia in "blast" crisis with the selective inhibitor of 5-lipoxygenase, SC41661A[3-(3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)hiol]-N-me thyl-N-[2-(2- phridinyl-propanamide)]. " 04/01/1993 - "We cultured chronic myelogenous leukemia cells from the peripheral blood of several patients in blast crisis with three inhibitors of lipoxygenases: ETYA, and the more selective A63162 (Abbott) or SC41661A (Searle). "
2.	Blast Crisis (Blast Phase) 01/01/1994 - "Cells were cultured from patients with chronic myelogenous leukemia in "blast" crisis with the selective inhibitor of 5-lipoxygenase, SC41661A[3-(3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)hiol]-N-me thyl-N-[2-(2- phridinyl-propanamide)]. " 04/01/1993 - "We cultured chronic myelogenous leukemia cells from the peripheral blood of several patients in blast crisis with three inhibitors of lipoxygenases: ETYA, and the more selective A63162 (Abbott) or SC41661A (Searle). "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/01/1993 - "Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/1998 - "The 5-lipoxygenase inhibitors ETYA, SC41661A and MK886 reduced the proliferation and viability of Panc-1 human pancreatic cancer cells. "
5.	Lung Neoplasms (Lung Cancer) 05/26/2001 - "The 5-lipoxygenase inhibitors SC41661A and MK886 with different mechanisms of action and the free radical spin trap, NTBN inhibit proliferation of the human bronchiolar lung cancer cell line NCI H-358 (5807 CRL). "

Related Drugs and Biologics

1.	Lipoxygenase Inhibitors
2.	5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
3.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
4.	MK-886
5.	Lipoxygenases
6.	Free Radicals
7.	N- hydroxy- N- (1- (4- (phenylmethoxy)phenyl)ethyl)- acetamide