mycalolide B

structure given in first source; isolated from the marine sponge Mycale

Also Known As:

mycalolide-B; Kabiramide C, 4-O-acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-23-demethyl-4-O-demethyl-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxo-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biological Toxins: 20
  - Marine Toxins: 124
    - mycalolide B: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - mycalolide B: 4

Experts

1.	Allingham, John S: 2 articles (12/2021 - 11/2018)
2.	Craig, Andrew W: 2 articles (12/2021 - 11/2018)
3.	Evans, P Andrew: 2 articles (12/2021 - 11/2018)
4.	Shah, Kavan: 2 articles (12/2021 - 11/2018)
5.	Aeluri, Madhu: 1 article (12/2021)
6.	Deng, Xu: 1 article (12/2021)
7.	Grange, Rebecca L: 1 article (12/2021)
8.	Pipaliya, Bhavin V: 1 article (12/2021)
9.	Trofimova, Daria N: 1 article (12/2021)
10.	Nersesian, Sarah: 1 article (11/2018)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 12/01/2021 - "Mycalolide B (MycB) is an actin-targeting marine macrolide that can suppress proliferation, migration, and invasion of breast and ovarian cancer cells at low nanomolar doses. " 11/22/2018 - "The growth and viability of human HER2+ breast cancer (HCC1954) and ovarian cancer (SKOV3) cell lines were significantly impaired upon treatment with the marine macrolide mycalolide B (Myc B) at doses above 100 nanomolar. "
2.	Leukemia 03/01/2013 - "Aplyronine A (1) and mycalolide B (2), which are cytotoxic actin-depolymerizing marine macrolides, were revealed to induce apoptosis in human leukemia HL60 cells and human epithelial carcinoma HeLa S(3) cells. "
3.	Carcinoma (Carcinomatosis) 03/01/2013 - "Aplyronine A (1) and mycalolide B (2), which are cytotoxic actin-depolymerizing marine macrolides, were revealed to induce apoptosis in human leukemia HL60 cells and human epithelial carcinoma HeLa S(3) cells. "
4.	Breast Neoplasms (Breast Cancer) 11/22/2018 - "The growth and viability of human HER2+ breast cancer (HCC1954) and ovarian cancer (SKOV3) cell lines were significantly impaired upon treatment with the marine macrolide mycalolide B (Myc B) at doses above 100 nanomolar. "
5.	Athetosis 09/01/2013 - "Gzm A-mediated athetosis did not require caspase activation, early mitochondrial disruption or generation of reactive oxygen species, but did require an intact actin cytoskeleton and was abolished by latrunculin B and mycalolide B. "

Related Drugs and Biologics

1.	Macrolides
2.	Caspases
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	aplyronine A
5.	latrunculin B