terpestacin

structure given in first source; isolated from Arthrinium; inhibits syncytium (giant cell) formation

Also Known As:

11-epiterpestacin; 1(3aH)-Cyclopentacyclopentadecenone, 4,7,8,9,12,13,16,16a-octahydro-2,7-dihydroxy-3-(2-hydroxy-1-methylethyl)-6,10,14,16a-tetramethyl-, (3aR-(3(S*),3aR*,5E,7S*,10E,14E,16aS*))-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        terpestacin: 5
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - terpestacin: 5

Experts

1.	Choi, Seung Hoon: 2 articles (12/2013 - 04/2010)
2.	Jung, Hye Jin: 2 articles (09/2013 - 04/2010)
3.	Kwon, Ho Jeong: 2 articles (09/2013 - 04/2010)
4.	Park, Ki Cheong: 1 article (12/2013)
5.	Chang, Junghwa: 1 article (09/2013)
6.	Kang, Sang Won: 1 article (09/2013)
7.	Kim, Jeong Hun: 1 article (09/2013)
8.	Kim, Yonghyo: 1 article (09/2013)
9.	Dong, Guangbin: 1 article (06/2010)
10.	Trost, Barry M: 1 article (06/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2010 - "Its promising anti-HIV and anti-cancer activity, as well as its novel structure, make terpestacin an attractive synthetic target. " 04/09/2010 - "These findings provide a novel molecular basis of terpestacin targeting UQCRB of Complex III in selective suppression of tumor progression." 09/01/2013 - "Furthermore, treatment with both terpestacin and bevacizumab, a VEGF signaling inhibitor, resulted in additive inhibition of tumor-induced angiogenesis both in vitro and in vivo. " 04/09/2010 - "Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing."
2.	Neuroblastoma 12/01/2013 - "Effects of endostatin and a new drug terpestacin against human neuroblastoma xenograft and cell lines."
3.	Glioblastoma (Glioblastoma Multiforme) 01/01/2023 - "Novel terpestacin derivatives with l-amino acid residue as anticancer agents against U87MG-derived glioblastoma stem cells."
4.	Hypoxia (Hypoxemia) 04/09/2010 - "Here we find that terpestacin, a small molecule previously identified in a screen of microbial extracts, binds to the 13.4-kDa subunit (UQCRB) of mitochondrial Complex III, resulting in inhibition of hypoxia-induced reactive oxygen species generation. " 04/09/2010 - "Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing."

Related Drugs and Biologics

1.	Endostatins
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)
5.	Oxygen (Dioxygen)
6.	Antineoplastic Agents (Antineoplastics)
7.	Amino Acids
8.	Bevacizumab (Avastin)