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BW B70C
arachidonic acid antagonist
Also Known As:
BW-B70C; N-(3-(3-(4-fluorophenoxy)phenyl)-1-methylprop-2-enyl)-N-hydroxyurea; Urea, N-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-N-hydroxy-
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Hydroxyurea: 3694
BW B70C: 4
Related Diseases
1.
Necrosis
12/27/1994 - "
BW B70C had no effect on either colloidal carbon retention or distribution but did significantly reduce tubular necrosis and calcification at day 3. There was very little inflammatory infiltrate.
"
04/11/1997 - "
The interference of the 5-lipoxygenase inhibitor, BW B70C ((E)-N-(3-[3-(4-fluorophenoxy)phenyl]-1(R,S)-methyl prop-2-enyl)-N-hydroxyurea), with Escherichia coli lipopolysaccharide (endotoxin)-induced lung leucocyte sequestration and microvascular albumin exchanges was evaluated in the anaesthetised guinea-pig using radioactive tracers, in parallel to the effects on cell counts in the broncho-alveolar lavage fluid, blood tumour necrosis factor (TNF-alpha) content, secretion of phospholipase A2 and synthesis of leukotriene C4 by alveolar macrophages.
"
2.
Acute Kidney Injury (Acute Renal Failure)
12/27/1994 - "
These data indicate that inhibition of LTB4 synthesis by BW B70C does not prevent the development of acute renal failure following 48 hr hypothermic storage and transplantation.
"
3.
Renal Insufficiency (Renal Failure)
12/27/1994 - "
BW B70C treatment did not improve the long-term viability of transplanted kidneys: 2/6 rabbits showed no symptoms of renal failure after 3 weeks.
"
4.
Kidney Neoplasms (Kidney Cancer)
03/31/2023 - "
Furthermore, using CMap, DrugMatrix and the LINCS L1000 chemical perturbation databases, we highlight putative repurposing drugs, including Etoposide, Haloperidol, BW-B70C, Triamterene, Chlorphenesin, BRD-K79459005 and β-Estradiol 3-benzoate, among others, that may reverse the expression of the identified co-DEGs in kidney cancers.
"
5.
Anaphylaxis (Anaphylactic Shock)
01/01/1993 - "
The actions of BW B70C, an orally available, biologically persistent and selective inhibitor of arachidonic acid 5-lipoxygenase, have been examined in two systems of anaphylaxis in actively sensitised guinea-pigs in vivo.
"
Related Drugs and Biologics
1.
Phospholipases A2 (Phospholipase A2)
2.
Leukotriene C4
3.
Lipoxygenase Inhibitors
4.
Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.
Triamterene (Dyrenium)
6.
Radioactive Tracers
7.
Lipopolysaccharides
8.
Leukotriene B4
9.
Hydroxyurea (Hydrea)
10.
Haloperidol (Haldol)
Related Therapies and Procedures
1.
Transplantation