tyrosyl- leucyl- N- methylphenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamide

exerts effect similar to opiate agonists on intestinal myoelectrical activity & on nociception in rats

Also Known As:

(1DME)Y8Fa; (1DMe)NPYF; (D-Tyr,(NMe)Phe3)neuropeptide FF; Tyr-Leu-(N-Me)-Phe-Gln-Pro-Gln-Arg-Phe-NH2; Tyr-Leu-(Nme)-Phe-Gln-Pro-Gln-Arg-Phe-NH2

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - tyrosyl-leucyl-N-methylphenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide: 3

Experts

1.	Panula, P: 2 articles (05/2001 - 01/2001)
2.	Pertovaara, A: 1 article (05/2001)
3.	Wei, H: 1 article (05/2001)
4.	Kalso, E: 1 article (01/2001)
5.	Kontinen, V K: 1 article (01/2001)
6.	Xu, M: 1 article (01/2001)

Related Diseases

1.	Inflammation (Inflammations) 01/01/1999 - "In carrageenan inflammation, 5-10 nmol of (1DMe)NPYF was effective against both thermal hyperalgesia and mechanical allodynia. " 01/01/2001 - "(1DMe)NPYF (5 nmol) had an antihyperalgesic effect in carrageenan inflammation and it significantly reduced mechanical allodynia in the spinal nerve ligation model. "
2.	Hyperalgesia 01/01/1999 - "In carrageenan inflammation, 5-10 nmol of (1DMe)NPYF was effective against both thermal hyperalgesia and mechanical allodynia. " 01/01/2001 - "(1DMe)NPYF (5 nmol) had an antihyperalgesic effect in carrageenan inflammation and it significantly reduced mechanical allodynia in the spinal nerve ligation model. "
3.	Pain (Aches) 01/01/1999 - "The results suggest a potential role for (1DMe)NPYF in the treatment of pain including neuropathic pain." 05/11/2001 - "The amide-group is essential for the [1DMe]NPYF-induced attenuation of pain." 05/11/2001 - "The present results indicate that [1DMe]NPYF produces a selective attenuation of pain in neuropathic animals due to naloxone-sensitive or -insensitive central mechanisms depending on the submodality of pain and route of drug administration. " 05/11/2001 - "Modulation of pain by [1DMe]NPYF, a stable analogue of neuropeptide FF, in neuropathic rats." 01/01/1999 - "Effects of (1DMe)NPYF, a synthetic neuropeptide FF analogue, in different pain models."
4.	Neuralgia (Stump Neuralgia) 01/01/1999 - "The results suggest a potential role for (1DMe)NPYF in the treatment of pain including neuropathic pain."

Related Drugs and Biologics

1.	Carrageenan
2.	phenylalanyl- leucyl- phenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamide
3.	Naloxone (Narcan)
4.	Amides

Related Therapies and Procedures

1.	Ligation