policosanol

aliphatic primary fatty alcohols 24-34 carbons long extracted from sugarcane (SACCHARUM) and SORGHUM, including 1-octacosanol (C28, 63%), 1-triacontanol (C30, 12.6%), hexacosanol (6.2%), 1-tetracosanol, 1-heptacosanol, 1-nonacosanol, 1-dotriacontanol, 1-tetratriacontanol

Networked: 122 relevant articles (23 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Illnait, J: 9 articles (02/2017 - 06/2000)
2.	Castaño, Gladys: 8 articles (06/2008 - 01/2002)
3.	Fernández, Lilia: 8 articles (06/2008 - 01/2002)
4.	Illnait, José: 8 articles (06/2008 - 01/2002)
5.	Fernández, L: 8 articles (01/2006 - 06/2000)
6.	Más, R: 8 articles (01/2006 - 06/2000)
7.	Castaño, G: 8 articles (01/2005 - 06/2000)
8.	Cho, Kyung-Hyun: 6 articles (01/2022 - 01/2018)
9.	Mas, R: 6 articles (02/2017 - 01/2001)
10.	Alvarez, E: 6 articles (01/2006 - 06/2000)

Related Diseases

1.	Hypercholesterolemia 01/01/2002 - "In conclusion, original policosanol at 5 and 10 mg/day, but not Octa 60, was effective in patients with type II hypercholesterolemia. " 05/01/2006 - "The aim of this study was to investigate the effects of combination treatment with Ω3FA (1 g/d) and policosanol (Ω3FA+Poli) compared with Ω3FA (1 g/d) plus placebo (Ω3FA+Pla) on platelet aggregation in human patients with hypercholesterolemia. " 01/01/2005 - "A comparison of the effects of D-003 and policosanol (5 and 10 mg/day) in patients with type II hypercholesterolemia: a randomized, double-blinded study." 03/01/2001 - "The present study was undertaken to investigate the effects of policosanol in older patients with type II hypercholesterolemia and more than one concomitant atherosclerotic risk factor. " 07/01/2000 - "The present study was conducted to determine whether policosanol administered orally to rabbits with exogenous hypercholesterolemia also protects against the development of atherosclerotic lesions. "
2.	Dyslipidemias (Dyslipidemia) 01/01/2018 - "Because of the high heterogeneity, the better treatment effects observed in the Cuban studies and the inconsistent dose-response relationship, more clinical trials are needed to further confirm the efficacy of policosanol on dyslipidemia." 01/01/2018 - "This study aimed to systematically investigate whether sugarcane policosanol was effective and safe on dyslipidemia. " 09/14/2023 - "Cuban Policosanol (Raydel®) Potently Protects the Liver, Ovary, and Testis with an Improvement in Dyslipidemia in Hyperlipidemic Zebrafish: A Comparative Study with Three Chinese Policosanols." 01/01/2018 - "A total of 11 databases including the PubMed, Web of science, Embase, Scopus, the Cochrane library and SinoMed databases were searched for available studies investigating the effects of policosanol on dyslipidemia. " 01/01/2018 - "Efficacy and safety of sugarcane policosanol on dyslipidemia: A meta-analysis of randomized controlled trials."
3.	Type 2 Diabetes Mellitus (MODY) 03/01/1995 - "We concluded that policosanol is effective and safe in patients with NIDDM and hypercholesterolemia." 03/01/1995 - "Treatment of hypercholesterolemia in NIDDM with policosanol." 01/01/1999 - "This randomized, double-blind study was undertaken to compare the efficacy and tolerability of policosanol (10 mg/day) and lovastatin (20 mg/day) in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus. " 01/01/1999 - "Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus." 01/01/2003 - "Policosanol (10 mg/day) for 8 weeks was less effective than similar doses of atorvastatin in reducing LDL-C and TC in patients with dyslipidaemia due to type 2 diabetes, but more effective in increasing HDL-C. "
4.	Hyperlipidemias (Hyperlipidemia) 01/01/2021 - "The aim of the study was to investigate the regulatory effects of policosanol on hyperlipidemia, gut microbiota and metabolic status in a C57BL/6 mouse model. " 01/01/2007 - "The supplements with the most supporting data were policosanol and garlic, both for hyperlipidemia. " 03/01/1996 - "Effect of policosanol on hyperlipidemia and coronary heart disease in middle-aged patients. " 01/01/2022 - "Further studies with cats demonstrating cardiometabolic risk factors are warranted to confirm whether policosanol therapy is an efficacious treatment for hyperlipidemia and obesity." 02/01/2005 - "Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol."
5.	Hypertension (High Blood Pressure) 08/01/2019 - "We aimed to systematically review all randomized control trials (RCTs) evaluating the efficacy of policosanol supplementation for lowering high blood pressure. " 01/01/2002 - "Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia." 01/01/2002 - "Policosanol administered long term is effective in lowering LDL-C and TC as well as increasing HDL-C levels in older patients with hypertension and type II hypercholesterolaemia without a history of CHD or cerebrovascular disease. " 01/01/2002 - "This study was conducted to investigate the effects of policosanol administered for 12 months on the lipid profile of older patients with hypertension and type II hypercholesterolaemia and no history of coronary heart disease (CHD) or cerebrovascular disease. " 01/01/2003 - "Three atorvastatin but no policosanol patients withdrew from the study because of adverse events: muscle cramps (1 patient), gastritis (1 patient) and uncontrolled hypertension, abdominal pain and myalgia (1 patient). "

Related Drugs and Biologics

1.	Cholesterol
2.	oxidized low density lipoprotein
3.	Lipids
4.	Sugars
5.	Aspirin (Acetylsalicylic Acid)
6.	Atorvastatin (Lipitor)
7.	Berberine
8.	red yeast rice
9.	Lovastatin (Mevacor)
10.	Warfarin (Coumadin)

Related Therapies and Procedures

1.	Canes (Cane)
2.	Therapeutics
3.	Ligation
4.	Subcutaneous Injections
5.	Drug Therapy (Chemotherapy)