creatine transporter

sodium dependent; found in vertebrate tissues; CT-1/CRT-1 & CT-2/CRT-2 are highly similar genes coding transporters with different tissue distribution; amino acid sequence in first source

Also Known As:

SLC6A10 protein; SLC6A8 protein; creatine transporter type 1; creatine transporter type 2; solute carrier-family-6 (neurotransmitter transporter, creatine), member 10; solute carrier-family-6 (neurotransmitter transporter, creatine), member 8

Networked: 72 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - creatine transporter: 72
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - creatine transporter: 72

Experts

1.	Salomons, Gajja S: 9 articles (01/2012 - 05/2002)
2.	Jakobs, Cornelis: 8 articles (01/2012 - 05/2002)
3.	Neubauer, Stefan: 7 articles (01/2016 - 02/2005)
4.	Lygate, Craig A: 6 articles (01/2016 - 11/2005)
5.	Battini, Roberta: 5 articles (01/2020 - 08/2007)
6.	Cioni, Giovanni: 5 articles (01/2020 - 08/2007)
7.	Leuzzi, Vincenzo: 5 articles (02/2013 - 12/2002)
8.	Rosenberg, Efraim H: 5 articles (07/2008 - 07/2004)
9.	Sebag-Montefiore, Liam: 4 articles (01/2013 - 11/2005)
10.	Clarke, Kieran: 4 articles (12/2012 - 02/2005)

Related Diseases

1.	Heart Failure 04/01/2010 - "Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity." 02/01/2005 - "The creatine transporter may be a potential therapeutic target to prevent energetic imbalance in heart failure." 12/01/2012 - "We therefore used mice overexpressing creatine transporter in the heart (CrT-OE) to test for the first time whether elevated creatine is beneficial in clinically relevant disease models of heart failure and ischaemia/reperfusion (I/R) injury. " 11/02/1999 - "Both in human and in experimental heart failure, creatine transporter protein content is reduced. " 01/01/2013 - "We therefore tested whether ribose would be beneficial in chronic heart failure in control mice and in mice with elevated myocardial creatine due to overexpression of the creatine transporter (CrT-OE). "
2.	Reperfusion Injury 01/01/2016 - "Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. " 01/01/2016 - "We have previously shown that mice over-expressing the creatine transporter (CrT-OE) have elevated intracellular creatine levels and are protected against ischaemia-reperfusion injury. "
3.	Intellectual Disability (Idiocy) 01/01/2019 - "Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. " 12/01/2013 - "Deficiency caused by mutations in the creatine transporter gene (SLC6A8/CT1) is an X-linked form of intellectual disability. " 01/01/2012 - "The creatine transporter (CRTR) defect is a recently discovered cause of X-linked intellectual disability for which treatment options have been explored. " 07/01/2006 - "X-linked creatine transporter (SLC6A8) mutations in about 1% of males with mental retardation of unknown etiology." 01/01/2008 - "Several studies reported on the role of X-linked creatine transporter mutations in individuals with mental retardation, with or without autism. "
4.	Autistic Disorder (Autism) 01/01/2008 - "Several studies reported on the role of X-linked creatine transporter mutations in individuals with mental retardation, with or without autism. "
5.	X-Linked Mental Retardation (Mental Retardation, X Linked) 03/01/2010 - "Creatine transporter (CRTR) deficiency is one of the most frequent causes of X-linked mental retardation. " 10/01/2004 - "Comparative frequency of fragile-X (FMR1) and creatine transporter (SLC6A8) mutations in X-linked mental retardation." 07/01/2006 - "Mutations in the creatine transporter gene, SLC6A8 (MIM 30036), located in Xq28, have been found in families with X-linked mental retardation (XLMR) as well as in males with idiopathic mental retardation (MR). " 05/01/2002 - "X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28." 07/01/2008 - "Creatine transporter deficiency is an X-linked mental retardation disorder caused by mutations in the creatine transporter gene, SLC6A8. "

Related Drugs and Biologics

1.	Creatine
2.	Ribose (D-Ribose)
3.	X-linked Creatine deficiency
4.	Arginine-Glycine Amidinotransferase Deficiency
5.	glycine amidinotransferase (arginine-glycine amidinotransferase)
6.	Guanidinoacetate N-Methyltransferase (Guanidinoacetate Methyltransferase)
7.	Proteins (Proteins, Gene)
8.	Phosphocreatine (Neoton)
9.	Phosphotransferases (Kinase)
10.	Mitochondrial Form Creatine Kinase

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Aftercare (After-Treatment)