5,7- dihydroxy- 6- methoxy- 2- phenylchromen- 4- one

10/01/2022 - "The compound oroxylin A (OA) is one among those with enormous potential against different malignancies. "
05/30/2018 - "Determination of oroxylin A and oroxylin A 7-O-d-glucuronide in HepG2 cell lysate and subcellular fractions with SPE-UPLC-MS/MS: Cellular pharmacokinetic study to indicate anti-cancer mechanisms."
01/01/2017 - "In previous studies, we have proved that oroxylin A reprogrammes metabolism of cancer cells by inhibiting glycolysis. "
04/23/2015 - "The studies have important implications for the investigation on anticancer effects of oroxylin A, and provide the academic basis for the clinical trial of oroxylin A in cancer patients."
08/01/2012 - "In vivo study, oroxylin A inhibited xenograft tumor growth and induced obvious autophagy in tumors. "

07/01/2012 - "The in-vivo chemopreventive efficacy of oroxylin A against HCT-116 human colon cancer was accompanied by its proapoptotic and Nrf2-inducing activities, which correlates with the in-vitro study. "
03/29/2016 - "We previously demonstrated that oroxylin A induced apoptosis in human colon cancer cells via the mitochondrial pathway. "
03/29/2016 - "Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53."
05/01/2015 - "UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells."
07/01/2012 - "This is the first demonstration of oroxylin A-dependent chemoprevention in colon cancer and may offer a potential mechanism for its anticancer action in vivo."

04/01/2016 - "These results suggested that oroxylin A was a potential therapeutic drug for treating allergic asthma. "
04/01/2016 - "In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. "
04/01/2016 - "In conclusion, these results suggested that oroxylin A inhibited airway inflammation in OVA-induced asthma murine model by inhibiting NF-κB activation. "
05/01/2016 - "A murine ovalbumin-induced allergic asthma model was used to test the in vivo efficacy of oroxylin A. "
05/01/2016 - "Because the root extracts of both plants have been shown to have anti-allergic effects, the authors investigated whether oroxylin A is likely to have beneficial effects on allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells. "

04/01/2021 - "The current study performed quantitative PCR, western blotting and cell immunofluorescence to evaluate the effect of Oroxylin A in chondrocyte inflammation. "
10/01/2014 - "Importantly, we showed for the first time that Nrf2 plays an important role in oroxylin A-suppressed inflammation in RAW264.7 cells. "
10/01/2014 - "Here we examine the mechanisms by which oroxylin A inhibits inflammation in RAW264.7 cells. "
01/01/2012 - "But whether oroxylin A suppresses the inflammation-induced angiogenesis is still unknown. "
04/01/2016 - "In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. "

01/01/2019 - "In this study, we examined the inhibiting effects of Oroxylin A on breast cancer cell proliferation, migration, and epithelial-mesenchymal transition (EMT) and its possible molecular mechanism. "
01/01/2019 - "These findings strongly suggest that Oroxylin A could be a therapeutic potential candidate for the treatment of breast cancer."
01/01/2019 - "Taken together, our results suggested that Oroxylin A inhibited the cell proliferation, invasion, migration, and EMT through inactivating NF-κB signaling pathway in human breast cancer cells. "
01/01/2019 - "Furthermore, we also found that supplement of TNF-α reversed the effects of Oroxylin A on the cell proliferation, invasion, migration, and EMT in breast cancer cells. "
01/01/2019 - "Moreover, cell proliferation, invasion, and migration of breast cancer cells were inhibited by Oroxylin A compared to the control. "