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saclofen

GABA-A receptor antagonist

Also Known As:

3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - Aminobutyrates: 1253
        gamma-Aminobutyric Acid: 8890
        Baclofen: 2556
        saclofen: 14

Experts

1.	Ba, Xiyuan: 1 article (01/2018)
2.	Chen, Zixian: 1 article (01/2018)
3.	Cheng, Xiaoe: 1 article (01/2018)
4.	Feng, Xiaojin: 1 article (01/2018)
5.	Guo, Jing: 1 article (01/2018)
6.	Hao, Yue: 1 article (01/2018)
7.	Hu, Xuexue: 1 article (01/2018)
8.	Jiang, Changyu: 1 article (01/2018)
9.	Jiang, Jin: 1 article (01/2018)
10.	Liu, Tao: 1 article (01/2018)

Related Diseases

1.	Pain (Aches) 01/01/2018 - "Moreover, the inhibitory effect of OT on capsaicin-induced facilitation of excitatory transmission was blocked by co-treatment with saclofen, while intrathecal administration of OT dramatically inhibited capsaicin-induced ongoing pain in rats, (n = 6, per group, P < 0.0001, saline vs. OT group). " 08/01/2016 - "Moreover, saclofen suppressed the release of the pro-inflammatory cytokines into the knee joint (ELISA) and pain-related behaviors (open field test). "
2.	Hyperalgesia 03/31/2010 - "Intrathecal administration of gabazine or saclofen blocked the relieving effects of ST36 EA stimulation on cold allodynia. " 07/01/2001 - "Desipramine (20 mg/kg, i.p.) significantly blocked the adjuvant-induced thermal hyperalgesia, which was facilitated by treatment with the GABA(A) antagonist picrotoxin (2 mg/kg, i.p.) or the GABA(B) antagonist saclofen (2 mg/kg, i.p.). "
3.	AIDS-Related Complex (ARC) 02/19/2008 - "Administration of the GABAB receptor antagonist saclofen and the GABAA receptor antagonist bicuculline selectively increased the rate of VMN cell movement in slices placed in vitro at embryonic day 14, when cells that form both the ARC and VMN are migrating away from the proliferative zone surrounding the third ventricle. " 01/29/2008 - "In more details, the effect of galanin on the membrane properties of Arc neurons is blocked by either lowering the extracellular Ca(2+) or the inhibition of GABA(B) receptors with the selective GABA(B) antagonist, saclofen. "
4.	Tachycardia (Tachyarrhythmias) 03/01/2016 - "By contrast, the concomitant LPS-evoked tachycardia and decreases in time domain and frequency domain indices of HRV (measures of cardiac autonomic control) were abolished upon treatment with bicuculline but not saclofen. "
5.	Spinal Cord Injuries (Spinal Cord Injury) 03/01/2008 - "At 4 weeks after Th9-10 spinal cord transection awake cystometry and recordings of external urethral sphincter electromyogram were performed to examine the effect of intrathecal application of the gamma-aminobutyric acid A and B agonists muscimol and baclofen or the gamma-aminobutyric acid A and B antagonists bicuculline and saclofen (Tocris Cookson, Ellisville, Missouri), respectively, at the level of the L6-S1 spinal cord. "

Related Drugs and Biologics

1.	Bicuculline
2.	gamma-Aminobutyric Acid (GABA)
3.	Baclofen
4.	GABA-B Receptor Antagonists
5.	GABA Receptors (GABA Receptor)
6.	GABA-B Receptor Agonists
7.	Galanin
8.	Glutamic Acid (Glutamate)
9.	GABA-B Receptors
10.	Cytokines