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transforming growth factor-beta type II receptor

Subscribe to New Research on transforming growth factor-beta type II receptor

expressed abundantly in ovary & lung; has an intracellular kinase domain; the rat form is 92% identical to the human form; amino acid sequence given in first source

Also Known As:

AAT3 protein, human; MFS2 protein, human; TGF-beta type II receptor; TGF-beta type II receptor, human; TGF-beta type II receptors; TGFBR-2 protein, human; TGFBR2 protein, human; TbetaR-II kinase; Tgfbr2 protein, mouse; Tgfbr2 protein, rat; receptor, transforming growth factor-beta type II; transforming growth factor, beta receptor II (70-80kDa) protein, human; transforming growth factor, beta receptor II, mouse; transforming growth factor, beta receptor II, rat; transforming growth factor-beta type II receptors; type II TGF-beta receptor; type II TGF-beta receptors

Networked: 293 relevant articles (2 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, S J: 8 articles (09/2003 - 01/2000)
2.	Moses, Harold L: 7 articles (07/2010 - 05/2003)
3.	Lee, Chung: 6 articles (01/2010 - 01/2005)
4.	Zhang, Qiang: 6 articles (01/2010 - 01/2005)
5.	Guo, Yinglu: 4 articles (01/2010 - 02/2006)
6.	Serra, Rosa: 4 articles (07/2008 - 03/2005)
7.	Gorska, Agnieszka E: 4 articles (01/2008 - 05/2003)
8.	Chytil, Anna: 4 articles (01/2008 - 03/2005)
9.	Arteaga, Carlos L: 4 articles (05/2007 - 06/2002)
10.	Takenoshita, S: 4 articles (09/2006 - 07/2000)

Related Diseases

1.	Radiation Injuries (Radiation Sickness) 11/01/2000 - "This study assessed whether in vivo administration of a soluble TGF-beta type II receptor (TbetaR-II) protein ameliorates intestinal radiation injury (radiation enteropathy). "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 04/01/2006 - "Combination gene therapy of HGF and truncated type II TGF-beta receptor for rat liver cirrhosis after partial hepatectomy." 03/01/2009 - "Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats." 03/02/1999 - "We eliminated type beta transforming growth factor (TGF-beta) signaling by adenovirus-mediated local expression of a dominant-negative type II TGF-beta receptor (AdCATbeta-TR) in the liver of rats treated with dimethylnitrosamine, a model of persistent liver fibrosis. "
3.	Neoplasms (Cancer) 02/01/2010 - "Subsequent studies showed that the CC chemokine regulated on activation, normal T cell expressed, and presumably secreted was up-regulated in invasive tumors and was required for invasion in cells with repressed levels of the transforming growth factor-beta type II receptor. " 02/01/2009 - "Importantly, mouse oral tumors can be followed by in vivo imaging, show metastatic spreading to regional lymph nodes, and display activation of nuclear factor-kappaB and signal transducer and activator of transcription-3 pathways and decreased transforming growth factor-beta type II receptor expression, thus resembling human counterparts. " 03/15/2008 - "Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype." 01/01/2005 - "No mutations in the type II TGF-beta receptor and Smad2 genes were observed in the tumors. " 03/01/2003 - "These mutations are similar to those of the 10-bp polyadenine tract within the TGF-beta type II receptor (TGFBR2), a well-characterized target of frameshift mutations in the same neoplasms. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/15/2006 - "Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma." 10/01/2000 - "Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma." 06/01/1999 - "Expression of transforming growth factor beta type II receptors in head and neck squamous cell carcinoma." 11/01/1997 - "Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck." 09/15/1995 - "Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells."
5.	Fibrosis (Cirrhosis) 07/01/2005 - "Remote delivery and expression of soluble type II TGF-beta receptor in muscle prevents hepatic fibrosis in rats." 10/01/2003 - "These results indicate the superiority of a soluble type II TGF-beta receptor over a dominant-negative, non-soluble type II TGF-beta receptor in the context of blocking renal fibrosis in murine models." 10/01/2003 - "The biologic activity of the type II TGF-beta receptor was evaluated in vitro by its ability to inhibit cellular proliferation and in vivo in a unilateral ureter obstruction fibrosis model. " 10/26/1999 - "In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis." 10/01/2009 - "Similar to tumors expressing dominant-negative TGF-beta type II receptor, histochemical studies revealed less fibrosis and increased angiogenesis in xenografted tumors expressing c-Ski compared to control tumors. "

Related Drugs and Biologics

1.	Transforming Growth Factor beta (TGF-beta)
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Dimethylnitrosamine (Nitrosodimethylamine)
4.	Transforming Growth Factor beta1 (TGF beta 1)
5.	Transforming Growth Factor beta3 (TGF beta 3)
6.	TGF-beta type I receptor
7.	Messenger RNA (mRNA)
8.	Histone Deacetylases (Histone Deacetylase)
9.	Carrier Proteins (Binding Protein)
10.	Retinaldehyde (Retinal)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Hepatectomy
4.	Aftercare (After-Treatment)