SDZ 216-525

structure given in first source; a selective 5-HT(1A) receptor antagonist

Also Known As:

SDZ-216-525; methyl 4-(4-(4-(1,1,3-trioxo-2H-1,2-benzoisothiazol-2-yl)butyl)-1-piperazinyl)-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 4-(4-(4-(3-oxo-1,2-benzisothiazol-2(3H)-yl)butyl)-1-piperazinyl)-, methyl ester, S,S-dioxide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Hypothermia 03/01/1993 - "At postsynaptic 5-HT1A receptors mediating hypothermia, eltoprazine, WY 48,723, MDL 72832 and tandospirone are agonists, zalospirone is a partial agonist and (-)-tertatolol, WAY 100,135, MDL 73005 EF and SDZ 216-525 are antagonists."
2.	Bites and Stings (Sting) 12/01/1993 - "Defensive evade was significantly attenuated at 20.0 mg/kg. SDZ 216-525 (0.025-1.0 mg/kg), a selective 5-HT1A antagonist, significantly attenuated offensive posturing and bite-attacks at 1.0 mg/kg, and all offensive behaviors nonsignificantly at the smaller doses tested. "

Related Drugs and Biologics

1.	Serotonin 5-HT1 Receptor Antagonists
2.	zalospirone
3.	eltoprazine
4.	binospirone mesylate
5.	MDL 72832
6.	tandospirone
7.	tertatolol (Artex)