LY 290324

a leukotriene D4 receptor antagonist

Also Known As:

5-(2-(1-(3-(2-(7-chloroquinolin-2-yl)ethenyl)benzyl)indol-7-yl)ethyl)-1H-tetrazole; LY-290324; LY290324; Quinoline, 7-chloro-2-(2-(3-((7-(2-(1H-tetrazol-5-yl)ethyl)-1H-indol-1-yl)methyl)phenyl)ethenyl)-, hydrochloride, (E)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - LY 290324: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - LY 290324: 1

Related Diseases

Bronchial Spasm

01/26/1993 - "Administered orally 6 h previously, LY290324 reduced LTC4, LTD4 and LTE4-induced bronchospasm with ED50s of 0.3, 0.28 and 0.37 mg/kg respectively. "
01/26/1993 - "Administered i.v. LY290324 prevented the development (ED50 = 3.4 micrograms/kg) of an LTD4-induced bronchospasm and readily reversed an established bronchospasm, but failed to prevent the bronchospasm to either histamine or platelet activating factor (PAF). "

Related Drugs and Biologics

1.	Leukotriene D4
2.	Leukotriene C4
3.	Platelet Activating Factor
4.	Histamine (Histamine Dihydrochloride)