tyrphostin 25

inhibits zymosan-stimulated PGE2 & LTC4 production; did not have any effect on human synovial fluid phospholipase A2 activity in vitro or on cyclooxygenase activity in the intact macrophage; did affect 5-lipoxygenase activity

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, F: 1 article (04/2001)
2.	Wang, X: 1 article (04/2001)
3.	Wu, R: 1 article (04/2001)
4.	Bursch, W: 1 article (04/2000)
5.	Ellinger, A: 1 article (04/2000)
6.	Hermann, R S: 1 article (04/2000)
7.	Hochegger, K: 1 article (04/2000)
8.	Marian, B: 1 article (04/2000)
9.	Torok, L: 1 article (04/2000)

Related Diseases

1.	Wounds and Injuries (Trauma) 04/10/2001 - "The change of beta-cat expression might mediate the airway epithelial injuries caused by smoking, and tyrphostin 25 might prevent such injuries through inhibiting the tyrosine kinase."
2.	Neurilemmoma (Schwannoma) 10/29/1998 - "Schwannoma cell stress fibers were inhibited by C3 transferase, tyrphostin A25, or dominant negative RhoA. "
3.	Infections 10/01/1996 - "Treatment of murine macrophage monolayers with genistein, herbimycin A, tyrphostin 25 or staurosporine prior to infection decreased parasite invasion in a dose-dependent manner. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/1997 - "Cocultures of human glioblastoma spheroids (derived from three separate patients) and fetal rat brain aggregates were examined for infiltration using confocal microscopy, in the presence of 0 to 100 mumol/L genistein, a tyrosine kinase (TK) inhibitor, and 3 mumol/L tyrphostin A25, a specific EGFR-TK inhibitor. "
5.	Colonic Neoplasms (Colon Cancer) 04/01/2000 - "For comparison, apoptotic or type I cell death was studied using the human colon cancer cell HT29/HI1 treated with the tyrosine kinase inhibitor tyrphostin A25 as a model. "

Related Drugs and Biologics

1.	Genistein
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	Staurosporine
4.	Transferases
5.	Tyrosine Kinase Inhibitors
6.	herbimycin