HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
RS 42358-197
a 5-hydroxytryptamine-3 receptor ligand; structure given in first source
Also Known As:
(3H)-RS-42358-197; (S)-N-(1-azabicyclo(2.2.2)oct-3-yl)-2,4,5,6-tetrahydro-1H-benzo(de)isoquinolin-1-one hydrochloride; RS-42358-197; 1H-Benz(de)isoquinolin-1-one, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,4,5,6-tetrahydro-, monohydrochloride, (S)-
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Bridged-Ring Heterocyclic Compounds
Heterocyclic Bridged Bicyclo Compounds
RS 42358-197: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
Tetrahydroisoquinolines: 44
RS 42358-197: 1
Related Diseases
1.
Vomiting
08/01/1993 - "
RS 42358-197, administered orally, also afforded protection against cisplatin-induced emesis in ferrets.
"
08/01/1993 - "
When tested at maximally effective doses against cisplatin-induced emesis in dogs, RS 42358-197 had a longer duration of antiemetic activity (> 6 h) than ondansetron (2 h).
"
08/01/1993 - "
In dogs, RS 42358-197, administered either intravenously or orally, dose-dependently inhibited the emesis induced by cisplatin, actinomycin and cyclophosphamide, but not that induced by apomorphine.
"
Related Drugs and Biologics
1.
Cisplatin (Platino)
2.
Ondansetron (Zofran)
3.
Dactinomycin (Actinomycin)
4.
Cyclophosphamide (Cytoxan)
5.
Apomorphine
6.
Antiemetics