neutrophil cytosol factor 67K

translocation of cytosolic component p67phox is essential step in the activation of NADPH oxidase in response to phorbol esters; amino acid sequence has been determined; subunit of leukocyte NADPH oxidase

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Networked: 97 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Hansen: 2 articles (01/2021 - 01/2021)
2.	Shen, Jiangang: 2 articles (01/2021 - 01/2021)
3.	Roesler, Joachim: 2 articles (07/2013 - 01/2012)
4.	Rösen-Wolff, Angela: 2 articles (07/2013 - 01/2012)
5.	Morio, Tomohiro: 2 articles (05/2013 - 01/2012)
6.	Toma, Tomoko: 2 articles (05/2013 - 01/2012)
7.	Yachie, Akihiro: 2 articles (05/2013 - 01/2012)
8.	Dang, Pham My-Chan: 2 articles (07/2012 - 09/2010)
9.	El-Benna, Jamel: 2 articles (07/2012 - 09/2010)
10.	Périanin, Axel: 2 articles (07/2012 - 09/2010)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2018 - "Turning off NADPH oxidase-2 by impeding p67phox activation in infected mouse macrophages reduced viral entry and inflammation." 01/01/2017 - "Glucose tolerance was reduced and markers of inflammation and oxidative stress (cyclooxygenase-2, gp91phox p22phox and p67phox) were increased in AT2R-/y mice compared to wild-type (WT) animals. " 03/01/2013 - "The capacity of dietary DHA to suppress hepatic markers of inflammation (Clec4F, F4/80, Trl4, Trl9, CD14, Myd88), fibrosis (Procol1α1, Tgfβ1), and oxidative stress (NADPH oxidase subunits Nox2, p22phox, p40phox, p47phox, p67phox) was significantly greater than dietary EPA. " 05/01/2008 - "Plaque oxidative stress, inflammation, and stability were quantified by NAD(P)H oxidase p67phox and MMP-2 immunoblotting, oxidized LDL (oxLDL) immunoreactivity, macrophage and Sirius red collagen staining. " 01/01/2020 - "Moreover, age-related increases in the mRNA expression of NADPH oxidase- and inflammation-related genes, including p67phox, p40phox, TNFα, and IL-6, in the kidney were suppressed in the O-SE and O-SE+VE groups. "
2.	Heart Failure 09/21/2023 - "In the heart failure model of mice and the hypertrophic model of cardiomyocytes, STA depressed NOX2 protein expression and activation, as shown by inhibited translocation of its phosphorylation, p67phox and p47phox, from the cytoplasm to the cell membrane. " 10/01/2015 - "Atorvastatin may improve cardiac function of rats with heart failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release." 10/01/2015 - "Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release." 10/01/2015 - "Atorvastatin treatment improved cardiac function of rats with isoproterenol-induced chronic heart failure and decreased the Rac1, p47phox and p67phox mRNA expressions. " 04/08/2008 - "Heart failure patients had significantly worse endothelial function than control subjects (15.2 +/- 3% vs. 40.5 +/- 8.4% relative relaxation; p < 0.05), elevated C-reactive protein (CRP) levels (8.6 +/- 2.7 mg/l vs. 2.6 +/- 0.4 mg/l; p < 0.05), over 2-fold higher NADPH-dependent superoxide generation (p < 0.05), and significantly higher expression of the Nox4 isoform and regulatory subunit p67phox. "
3.	Osteomyelitis 01/01/1999 - "This report indicates the use of interferon gamma might be helpful in control for Aspergillus osteomyelitis of the tibia in a child with CGD demonstrated p67-phox deficiency refractory to conventional therapy with AMPH."
4.	Infarction (Infarctions) 01/01/2021 - "We found that 1) ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurological deficit scores in the post-ischemic stroke rats; 2) Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3) Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4) Ethanol extract of DSS significantly down-regulated the expression of p67phox but has no effect on p47phox and iNOS statistically. "
5.	Fibrosis (Cirrhosis) 03/01/2013 - "The capacity of dietary DHA to suppress hepatic markers of inflammation (Clec4F, F4/80, Trl4, Trl9, CD14, Myd88), fibrosis (Procol1α1, Tgfβ1), and oxidative stress (NADPH oxidase subunits Nox2, p22phox, p40phox, p47phox, p67phox) was significantly greater than dietary EPA. "

Related Drugs and Biologics

1.	NADPH Oxidases (NAD(P)H oxidase)
2.	Superoxides (Superoxide)
3.	neutrophil cytosol factor 40K
4.	Messenger RNA (mRNA)
5.	Peroxynitrous Acid (Peroxynitrite)
6.	Caspase 3 (Caspase-3)
7.	Isoproterenol (Isoprenaline)
8.	Interferon-gamma (Interferon, gamma)
9.	Ethanol (Ethyl Alcohol)
10.	Atorvastatin (Lipitor)

Related Therapies and Procedures

1.	Therapeutics