Disulfiram FDA Link

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Also Known As:

Antabuse; Antabus; Alcophobin; Anticol; Bis(diethylthiocarbamoyl) Disulfide; Dicupral; Esperal; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2; Teturam; Disulfide, Tetraethylthiuram; Tetraethylthiuram Disulfide; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-

Pharmalogical Action Categories:

Acetaldehyde Dehydrogenase Inhibitors
Alcohol Deterrents

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - Thiocarbamates: 27
        Ditiocarb: 342
        Disulfiram: 1619
- Sulfur Compounds: 278
  - Sulfides: 1062
    - Disulfides: 2363
      - Disulfiram: 1619
  - Thiocarbamates: 27
    - Ditiocarb: 342
      - Disulfiram: 1619

4-methylpiperazino-thiuramdisulfide

Bio-Agent Context: Research Results