RTI 121

structure given in first source; selectively binds to dopamine transporters

Also Known As:

3beta-(4-iodophenyl)tropan-2beta-carboxylic acid isopropyl ester; IPCIT; RTI-121; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl-, 1-methylethyl ester, (1R-(exo,exo))-

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Barnett, Miya L: 1 article (11/2021)
2.	Corcoran, Frederique: 1 article (11/2021)
3.	Green Rosas, Yessica: 1 article (11/2021)
4.	Jent, Jason F: 1 article (11/2021)
5.	Rastogi, Medini: 1 article (11/2021)
6.	Sigal, Marika: 1 article (11/2021)
7.	Comer, Jonathan S: 1 article (01/2020)
8.	Fleming, Georgette E: 1 article (01/2020)
9.	Furr, Jami M: 1 article (01/2020)
10.	Kimonis, Eva R: 1 article (01/2020)

Related Diseases

1.	COVID-19 11/01/2021 - "This mixed methods study conducted a follow-up survey to gather therapist experiences (N = 223) in delivering iPCIT during COVID-19, including qualitative data on the benefits and challenges to delivering iPCIT. " 01/01/2023 - "PCIT was adapted for telehealth delivery, internet-delivered PCIT (iPCIT), before the COVID-19 pandemic but was not widely implemented until the rapid transition to telehealth during stay-at-home orders. " 11/01/2021 - "Of the 183 therapists who transitioned to deliver PCIT via telehealth, 82% expressed interest in continuing to provide iPCIT following the COVID-19 pandemic. "
2.	Attention Deficit and Disruptive Behavior Disorders (Disruptive Behavior Disorder) 01/01/2020 - "Forty families (57.6% non-Hispanic Caucasian) with a 3-5 year-old (M = 3.95 years, SD = 0.9; 83.5% boys) child with a disruptive behavior disorder were randomized to either iPCIT or clinic-based PCIT. "
3.	Parkinson Disease (Parkinson's Disease) 05/01/2004 - "Nigrostriatal denervation was similar between dyskinetic and non-dyskinetic Parkinson's disease patients, as assessed with catecholamine concentrations and [125I]RTI-121-specific binding to dopamine transporters. "
4.	Dystonia (Limb Dystonia) 01/01/1998 - "Dopamine (DA) uptake sites, or transporters, were examined with [125I]RTI-121 in mutant mice that exhibit motor control deficits, namely weaver, lurcher and dystonia musculorum. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Catecholamines

Related Therapies and Procedures

1.	Denervation