damnacanthal

12/01/2018 - "Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent. "
05/01/2015 - "Since mast cells are key players in various inflammatory conditions as well as in cancer, we considered the possibility that the biological actions of damnacanthal, at least partly, could be due to effects on mast cells. "
06/01/2014 - "This review aims to discuss the biological properties of damnacanthal, specifically on its anti-cancer activity that has been reported. "
08/20/2013 - "The target compound damnacanthal (1) was found to be the most cytotoxic against the MCF-7 and K-562 cancer cell lines, with IC50 values of 3.80 ± 0.57 and 5.50 ± 1.26, respectively. "
03/01/2010 - "Interestingly, the damnacanthal had potent cytotoxicity against all cancer cell lines and Vero cell lines. "

06/01/2022 - "This study aimed to investigate the mechanisms underlying damnacanthal's effects against ovarian cancer. "
06/01/2022 - "Damnacanthal inhibited the growth of ovarian cancer via the ERK/mTOR/autophagy signaling cascade, indicating that it may be a potential anti-ovarian cancer drug candidate."
06/01/2022 - "In vivo experiments, the anti-ovarian cancer effect of damnacanthal was further evaluated in a xenograft nude mouse model of SKVO3 cells. "
06/01/2022 - "In vitro experiments, CCK8, colony formation and flow cytometry assays were used to evaluate the anti-ovarian cancer effect of damnacanthal on SKVO3 and A2780 cells. "
06/01/2022 - "Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy."

01/01/2022 - "These results reveal the potential therapeutic activity of a natural damnacanthal compound as an anti-colorectal cancer drug."
01/01/2022 - "We found that the growth of human colorectal cancer cells was inhibited by damnacanthal in a dose- and a time-dependent manner. "
08/01/2012 - "Taken together, these results indicate that damnacanthal increases antitumorigenic activity in human colorectal cancer cells and that C/EBPβ plays a role in damnacanthal-induced NAG-1 expression."
08/01/2012 - "Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells."
01/01/2022 - "In vitro analyses further indicated that morindone and damnacanthal have significant cytotoxicity effect and selectivity activity against colorectal cancer cell lines."

05/01/2014 - "Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells."
09/01/2019 - "Development of biodegradable sustained-release damnacanthal nanocapsules for potential application in in-vitro breast cancer studies."
09/14/2016 - "Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro."
01/01/2015 - "These results indicate that DHAQC (2) is a synthetic, cytotoxic, and selective anthraquinone, which is less toxic than the natural product damnacanthal, and which demonstrates potential in the induction of apoptosis in the breast cancer MCF-7 cell line. "
09/14/2016 - "This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. "

01/01/2022 - "This study aimed to measure acute oral toxicity and to investigate the anticancer activity of damnacanthal in colorectal tumorigenesis. "
01/01/2022 - "Acute oral toxicity of damnacanthal and its anticancer activity against colorectal tumorigenesis."
08/01/2012 - "In this report, we examined systematic approaches on the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. "