quercetagetin

structure given in first source; inhibits aldose reductase in rat lens

Also Known As:

3,5,6,7,3',4'-hexamethoxyflavone; 3,5,6,7-Tetrahydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one; quercetogetin; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-

Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        quercetagetin: 13
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        quercetagetin: 13

Experts

1.	Chen, Hua: 1 article (06/2016)
2.	Gao, Yanxiang: 1 article (06/2016)
3.	Liu, Fuguo: 1 article (06/2016)
4.	Tai, Kedong: 1 article (06/2016)
5.	Wang, Weiyou: 1 article (06/2016)
6.	Xu, Honggao: 1 article (06/2016)
7.	Abu Bakar, Sazaly: 1 article (01/2016)
8.	Chu, Justin Jang Hann: 1 article (01/2016)
9.	Hassandarvish, Pouya: 1 article (01/2016)
10.	Higgs, Stephen: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2015 - "Induction of mitosis-associated tumor cell death by quercetagetin is a promising strategy for developing novel chemotherapeutic anticancer agents. " 01/23/2013 - "Our study suggests the potential use of quercetagetin in the prevention or therapy of cancer and other chronic diseases." 05/08/2023 - "The non-bond interactions of each of the compounds with EGFR, such as Gossypetin interacting with active site MET769 and ASP831; Muxiangrine III interacting with MET769 and ASP831; Quercetagetin showing non-bonded interactions with GLU738, GLN767, and MET769 for >100% of the simulation timeframe These findings suggest further research into these compounds, which can yield a potential phytochemical drug against cancer.Communicated" 02/01/1994 - "Artemisinin and quercetagetin 6,7,3',4'-tetramethyl ether showed significant cytotoxicity against P-388, A-549, HT-29, MCF-7, and KB tumor cells." 05/01/2012 - "Taken together, these results demonstrate that among the major flavonoids of citrus, apigenin and quercetagetin have potent anti-cancer activity through inducing apoptosis in SW480 human colon cancer cells."
2.	Inflammation (Inflammations) 09/01/2014 - "Furthermore, quercetagetin augmented the expression of TGF-β1, which is known to modulate the immune response and inflammation. " 01/01/2022 - "As the mechanism's scope would apply to the diverse range of virus species that elicit inflammation in infected hosts, we highlight pre-clinical studies of polyphenol aglycones, such as luteolin, isoginkgetin, quercetin, quercetagetin, baicalein, curcumin, fisetin and hesperetin that reduce virion replication spanning multiple distinct virus genera. "
3.	Chronic Disease (Chronic Diseases) 01/23/2013 - "Our study suggests the potential use of quercetagetin in the prevention or therapy of cancer and other chronic diseases."
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2007 - "Quercetagetin was able to inhibit PIM1 activity in intact RWPE2 prostate cancer cells in a dose-dependent manner (ED(50), 5.5 micromol/L). " 01/04/2023 - "The cytotoxicity of 6-Hydroxykaempferol 3,7-dimethyl ether and quercetagetin 3,7,3’-trimethyl ether (chrysosplenol C), which are major flavonols isolated from the plant, were tested on prostate epithelial cells (PNT2), prostate cancer cells (DU145 and PC3), human keratinocytes (HaCaT), and melanoma cells (HTB140 and A375). "
5.	Infections 11/01/1997 - "Inhibition of tomato bushy stunt virus infection using a quercetagetin flavonoid isolated from Centaurea rupestris L." 01/01/2016 - "Baicalein, fisetin, and quercetagetin displayed potent inhibition of CHIKV infection, with 50% inhibitory concentrations [IC50] of 1.891 μg/ml (6.997 μM), 8.444 μg/ml (29.5 μM), and 13.85 μg/ml (43.52 μM), respectively, and with minimal cytotoxicity. "

Related Drugs and Biologics

1.	Quercetin
2.	fisetin
3.	baicalein
4.	Polyphenols
5.	Luteolin
6.	Curcumin
7.	isoginkgetin
8.	hesperetin
9.	Flavonoids
10.	Ether (Diethyl Ether)

Related Therapies and Procedures

1.	Therapeutics