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tecogalan

bacteria-derived sulfated polysaccharide isolated from an Arthrobacter sp.; has antiangiogenic activity

Also Known As:

D-gluco-D-galactan sulfate; DS 4152; DS-4152; tecogalan sodium

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Bacterial Polysaccharides: 50
    - tecogalan: 6
Biological Factors: 2472
- Antigens: 143924
  - Bacterial Antigens: 807
    - Bacterial Polysaccharides: 50
      - tecogalan: 6

Experts

1.	Calza, Roberta: 1 article (10/2005)
2.	Corallini, Alfredo: 1 article (10/2005)
3.	Margiotta, Chiara: 1 article (10/2005)
4.	Possati, Laura: 1 article (10/2005)
5.	Rocchetti, Romina: 1 article (10/2005)
6.	Talevi, Simona: 1 article (10/2005)
7.	Wellstein, A: 1 article (01/2001)
8.	Yunmbam, M K: 1 article (01/2001)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2001 - "Based on our previous studies with these models, we conclude, that tecogalan acts by blocking HBGFs released from tumor cells. " 01/01/2001 - "Subcutaneous growth of tumors was inhibited by once weekly i.v. administration of tecogalan. " 12/01/1989 - "On the other hand, the survival of mice with ascitic M5076 tumors was not affected by the combination of DS-4152 plus tetrahydro S. " 12/01/1989 - "The antitumor effects of DS-4152 administered in combination with a steroid whose dose level did not affect tumor growth were examined. " 12/01/1989 - "In the presence of cortisone acetate or tetrahydro S, DS-4152 suppressed chick chorioallantoic membrane angiogenesis and murine tumor M5076 cell-induced s.c. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/1994 - "In order to determine this possibility, consequences of DS-4152 infusion on HIV-1 p24 serum levels and CD4+ cell counts over time are being examined in ongoing clinical trials in the United States on patients with AIDS-associated KS."
3.	Kaposi Sarcoma (Kaposi's Sarcoma) 01/01/1994 - "A sulfated polysaccharide-peptidoglycan DS-4152 has recently been identified as a potent and selective inhibitor of Kaposi's sarcoma (KS). " 01/01/1995 - "Tecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. "
4.	Corneal Neovascularization 01/01/1995 - "Since bFGF is known to have a promoting effect on corneal neovascularization, tecogalan sodium may be possible therapeutic agent for corneal neovascularization, which can cause severe visual disturbances." 01/01/1995 - "Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose-dependent manner. " 01/01/1995 - "The antiangiogenic effect of tecogalan sodium on corneal neovascularization was investigated. " 01/01/1995 - "Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor."
5.	Experimental Melanoma 12/01/1989 - "DS-4152 significantly inhibited the growth of s.c.-implanted B16 melanoma in combination with cortisone acetate. "

Related Drugs and Biologics

1.	Polysaccharides (Glycans)
2.	Peptidoglycan (Murein)
3.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Tetracycline (Achromycin)
6.	Steroids
7.	Minocycline (Cyclops)
8.	Hormones (Hormone)
9.	Heparin (Liquaemin)
10.	Cortisone