I-antigen

used as a marker for well-differentiated leukemia cells; carbohydrate structure of immunodominant epitope is Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3R which is very similar to that of sialyl SSEA-1

Also Known As:

Networked: 210 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	van Hall, Thorbald: 4 articles (01/2019 - 04/2011)
2.	Ferrone, Soldano: 2 articles (01/2022 - 01/2020)
3.	Paschen, Annette: 2 articles (01/2021 - 01/2020)
4.	Thier, Beatrice: 2 articles (01/2021 - 01/2020)
5.	Doorduijn, Elien M: 2 articles (01/2019 - 02/2016)
6.	Bührer-Sékula, Samira: 2 articles (01/2018 - 01/2012)
7.	Lapointe, Réjean: 2 articles (01/2017 - 06/2015)
8.	Reuben, Alexandre: 2 articles (01/2017 - 06/2015)
9.	Santos, Manuela M: 2 articles (01/2017 - 06/2015)
10.	Oliveira, Cláudia C: 2 articles (02/2016 - 11/2014)

Related Diseases

1.	Infections 04/01/2011 - "The objective of this study was to determine whether immunization of Mozambique tilapia with different Cryptocaryon irritans i-antigen serotypes elicited cross-protection against challenge infection by both serotypes. " 12/01/1988 - "The aim of this study was to investigate whether I antigen occurs in association with Mycoplasma pneumoniae in a form that may be immunogenic during natural infection or experimental immunization. " 01/01/2019 - "Overall, our findings show that concurrent IFN-I treatment of TO-cells and SAV3 infection enriched gene expression linked to the MHC-I antigen presentation pathway. " 01/01/2019 - "Transcriptome Analysis Shows That IFN-I Treatment and Concurrent SAV3 Infection Enriches MHC-I Antigen Processing and Presentation Pathways in Atlantic Salmon-Derived Macrophage/Dendritic Cells." 02/01/2011 - "The loss of expression of HLA-I antigen was significantly correlated with part of the APM components and positively correlated with high risk HPV16 infection. "
2.	Neoplasms (Cancer) 01/01/2022 - "Further, we demonstrated that the OAd-MUC16-BiTE-mediated anti-tumor activity is related to the reversal of the TME and improved MHC I antigen presentation. " 01/01/2023 - "Since MHC-I antigen presentation is not essential for cell growth or survival, many cancers inactivate this pathway, and thereby escape control by CD8 T cells. " 01/01/2023 - "This later gained momentum upon the discovery of CD8 + T cells able to recognize and kill cancer cells in an MHC-I antigen-restricted manner. " 01/01/2022 - "We have engineered an MHC I/antigen: TCR-matched panel of human NSCLC cancer and T cells to identify tumor cell-intrinsic T cell resistance mechanisms. " 01/01/2022 - "Further transcriptomic dissection indicated that loss of MHC-I antigen presentation on tumor cells plays a critical role in the reduction of T cell infiltration during drug resistance. "
3.	Plague (Bubonic Plague) 01/01/2006 - "Administration of highly immunogenic (ED50 12.6 mcg/mouse) F I antigen (100 mcg/mouse) to albino mice 5 hours after their contamination approximately with 1000 LD50 of Yersinia pestis 231 provided 99-percent survival of same animals (17-50%) and 2-5-day prolongation of the life-span, that was indicative of the phenomenon analogous to the survival phenomenon observed in infected animals immunized by immunogenic strains of the plague microbe. " 11/01/1992 - "A comparative study was performed on the efficacy of doxycycline in experimental plague infection induced in albino mice by strain 231 of the plague microbe and its variant 231 Fra- deprived of the ability to produce the fraction I antigen. " 07/01/1983 - "[Detection and characterization of the plasmids of the plague microbe which determine the synthesis of pesticin I, fraction I antigen and "mouse" toxin exotoxin]." 11/01/1982 - "A rapid and sensitive radioimmunoassay for the detection of soluble Yersinia pestis fraction I antigen using antibody-coated beads and radiolabeled immunoglobulin was applied to spleen-liver extracts, rendered noninfectious by either treatment or filtration, from rodents dead of plague. " 01/01/1953 - " tests to establish the correlation between antibody response following inoculation with plague antigens or vaccines and resistance to infection showed that inoculation of 30mug of Fraction I antigen consistently protected mice against P. "
4.	Neoplasm Metastasis (Metastasis) 04/01/2007 - "HPV16 E7 may play an important role in the downregulation of HLA-I antigen in cervical lesions, which results in the immune escape of the virus and the occurrence, development, invasion and metastasis of cancer. " 04/01/1997 - "The serum levels of sialyl Lewis X-i antigen may reflect the extension of metastasis and would be helpful in considering treatment options." 01/01/1998 - "Serum levels of sialyl Lewis X-i antigen in 21 patients who developed lung metastasis during the period were significantly higher than those in 100 patients who did not develop lung metastasis (p = 0.0171). " 01/01/1998 - "Before treatment, serum levels of sialyl Lewis X-i antigen were significantly higher in patients with lung metastasis than in those without lung metastatis (p = 0.0001). " 01/01/1998 - "Elevated serum sialyl Lewis X-i antigen levels in non-small cell lung cancer with lung metastasis."
5.	Salpingitis 12/01/1980 - "The immune response to Protein I antigen may thus provide serotype-specific protection against gonococcal salpingitis."

Related Drugs and Biologics

1.	Sialyl Lewis X Antigen
2.	Proteins (Proteins, Gene)
3.	Leucine (L-Leucine)
4.	Doxycycline (Periostat)
5.	Antibodies
6.	Immunoglobulin G (IgG)
7.	Antigens
8.	Immunoglobulin M (IgM)
9.	Autoantibodies
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
5.	Intraperitoneal Injections