nuclear scaffold serine protease

calcium-regulated serine protease which cleaves a subset of lamins A/C (intermediate filament proteins) to produce an ATP-binding protein; partial amino-terminal amino acid sequence given in first source

Also Known As:

NS protease

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        nuclear scaffold serine protease: 1
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        nuclear scaffold serine protease: 1

Experts

1.	Claus, Claudia: 1 article (10/2007)
2.	Frey, Teryl K: 1 article (10/2007)
3.	Liebert, Uwe G: 1 article (10/2007)
4.	Tzeng, Wen-Pin: 1 article (10/2007)

Related Diseases

Superinfection

10/01/2007 - "However, cleavage of a precursor translated from a supertransfecting replicon transcript with an NS protease catalytic-site mutation was not detected and the event in the replication cycle at which superinfection exclusion is executed remains to be elucidated."
10/01/2007 - "We tested the hypothesis favoured in the related alphaviruses that superinfection exclusion is mediated by cleavage of the incoming non-structural precursor by the pre-existing non-structural (NS) protease, resulting in an inhibition of minus-strand RNA synthesis. "

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)