HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2,3,5-(triglutathion-S-yl)hydroquinone

Also Known As:

2,3,5-(triGSyl)HQ; 2,3,5-tris-(glutathion-S-yl)hydroquinone

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Glutathione: 14524
      - 2,3,5-(triglutathion-S-yl)hydroquinone: 6
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroquinones: 47
        2,3,5-(triglutathion-S-yl)hydroquinone: 6

Experts

1.	Lau, Serrine S: 4 articles (11/2011 - 08/2002)
2.	Monks, Terrence J: 4 articles (11/2011 - 08/2002)
3.	Cohen, Jennifer D: 2 articles (11/2011 - 08/2011)
4.	Dietrich, Justin D: 1 article (11/2011)
5.	Gard, Jaime M C: 1 article (11/2011)
6.	Nagle, Raymond B: 1 article (11/2011)
7.	Gallegos, Alfred C: 1 article (08/2011)
8.	Mastrandrea, Nicholas J: 1 article (08/2011)
9.	Tham, Kimberly Y: 1 article (08/2011)
10.	Habib, Samy L: 1 article (03/2003)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2002 - "Although 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ; 2.5 micromol/kg ip) markedly increased cell proliferation within the outer stripe of the outer medulla (OSOM) of the kidney in both wild-type (Tsc2(+/+)) and mutant Eker rats (Tsc2(EK/+)), only TGHQ-treated Tsc2(EK/+) rats developed renal tumors, indicating that cell proliferation per se was not sufficient for tumor development. " 11/01/2011 - "Critical proteins in both pathways are activated following treatment of Eker rats (Tsc-2(EK/+)) with the nephrocarcinogen 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ), which also results in loss of the wild-type allele of Tsc-2 in renal preneoplastic lesions and tumors. " 03/01/2003 - "Treatment of wild-type (Tsc-2(+/+)) and mutant (Tsc-2(EK/+)) Eker rats with 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ; 7.5 micro mol/kg. i.v.), a potent redox active and nephrotoxic metabolite of hydroquinone increases the incidence of renal tumors only in animals carrying the mutant Tsc-2(EK/+) allele. " 08/01/2011 - "Renal tumors derived from 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-treated Tsc-2(EK/+) rats, and null for tuberin, display elevated nuclear and cytosolic p27, with parallel increases in cytosolic cyclin D1 levels. "
2.	Necrosis 10/01/1995 - "Although, the activity of gamma-GT was similar in mice and guinea pigs, only guinea pigs were susceptible to 2,3,5-(triGSyl)HQ (200 micromol/kg iv)-induced renal necrosis. " 12/01/1992 - "Administration of 2,3,5-(triglutathion-S-yl)hydroquinone [2,3,5-(triGSyl)HQ] to rats causes severe renal proximal tubular necrosis. " 12/01/1992 - "A total collapse in RRM function occurred by 24 hr. The effects of 2,3,5-(triGSyl)HQ on state 4 respiration preceded significant elevations in blood urea nitrogen, which occurred at 8 hr. However, pretreatment of animals with probenecid, an inhibitor of organic anion transport, caused a significant decrease in the 2,3,5-(triGSyl)HQ-mediated elevations in state 4 respiration at 1 hr, without preventing the subsequent development of renal necrosis. "

Related Drugs and Biologics

1.	trans-sodium crocetinate (crocetin)
2.	Cyclin D1
3.	Urea (Carbamide)
4.	Proteins (Proteins, Gene)
5.	Probenecid (Benemid)
6.	Nitrogen
7.	Anions
8.	Tuberous Sclerosis Complex 2 Protein
9.	hydroquinone (Esoterica)