perillic acid

d-limonene metabolite; structure given in first source

Also Known As:

4-(1-methylethenyl)-1-cyclohexene-1-carboxylic acid; 4-(2-propenyl)-1-cyclohexane-1-carboxylic acid; 4-isopropenylcyclohex-1-ene carboxylic acid; NSC 667676; NSC-667676

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Monoterpenes: 522
      - perillic acid: 12
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        perillic acid: 12

Experts

1.	Raphael, T J: 2 articles (01/2010 - 09/2003)
2.	Fujii, Akihiko: 1 article (01/2018)
3.	Hase, Tadashi: 1 article (01/2018)
4.	Hashizume, Kohjiro: 1 article (01/2018)
5.	Kitamura, Naoya: 1 article (01/2018)
6.	Kondo, Hidehiko: 1 article (01/2018)
7.	Murase, Takatoshi: 1 article (01/2018)
8.	Nakamura, Junji: 1 article (01/2018)
9.	Nishino, Machiko: 1 article (01/2018)
10.	Ohuchi, Atsushi: 1 article (01/2018)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1998 - "In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines. "
2.	Neoplasms (Cancer) 08/22/2022 - "At that time, a final dose of NEO100 was given shortly before the tumor tissue was surgically removed, and the tissue was processed for high-performance liquid chromatography analysis of POH and its primary metabolite, perillic acid (PA). " 12/15/2001 - "Monoterpenes [limonene, perillic acid (PA) and its derivatives] have been shown to inhibit cell growth and protein prenylation in cancer cells. "
3.	Colonic Neoplasms (Colon Cancer) 07/26/2002 - "To establish the molecular mechanisms of POH and its major metabolite perillic acid (PA) as anti-proliferative agents, their effects on cell proliferation, cell cycle and cell cycle regulatory proteins were studied in HCT 116 human colon cancer cells. " 08/15/2023 - "Platinum(IV) combo prodrugs containing cyclohexane-1R,2R-diamine, valproic acid, and perillic acid as a multiaction chemotherapeutic platform for colon cancer."
4.	Dyslipidemias (Dyslipidemia) 07/01/2023 - "The results showed that hyperlipemia induced dyslipidemia in rats, which was alleviated by ginsenoside Rb_1. The non-targeted metabolomics results showed that there were 297 differential metabolites in the liver tissues of hyperlipidemia rats, 294 differential metabolites in the serum samples, and 560 diffe-rential metabolites in the hyperlipidemia rats treated by ginsenoside Rb_1. Perillic acid and N-ornithyl-L-taurine were common metabolites in the liver and serum samples, which could be used as potential biomarkers for ginsenoside Rb_1 in the improvement of hyperlipidemia. "
5.	Neoplasm Metastasis (Metastasis) 09/01/2003 - "Effect of naturally occurring monoterpenes carvone, limonene and perillic acid in the inhibition of experimental lung metastasis induced by B16F-10 melanoma cells."

Related Drugs and Biologics

1.	Monoterpenes (Monoterpenoids)
2.	Limonene
3.	perillyl alcohol
4.	Cyclin D1
5.	Ginsenosides
6.	Cell Cycle Proteins
7.	ras Proteins
8.	Biomarkers (Surrogate Marker)
9.	Valproic Acid (Depakote)
10.	Taurine

Related Therapies and Procedures

1.	Intranasal Administration