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simian immunodeficiency virus gp130

has been sequenced; does not protect from challenge infection

Also Known As:

SIV gp130

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Structural Proteins: 171
      - Viral Envelope Proteins: 291
        env Gene Products: 219
        simian immunodeficiency virus gp130: 4
    - Retroviridae Proteins: 7
      - env Gene Products: 219
        simian immunodeficiency virus gp130: 4
  - Polyproteins: 445
    - env Gene Products: 219
      - simian immunodeficiency virus gp130: 4

Experts

1.	Binley, James M: 1 article (12/2006)
2.	Connor, Ruth I: 1 article (12/2006)
3.	Gettie, Agegnehu: 1 article (12/2006)
4.	Marx, Preston: 1 article (12/2006)
5.	Metzner, Karin J: 1 article (12/2006)
6.	Nixon, Douglas F: 1 article (12/2006)

Related Diseases

1.

02/15/1996 - "Simian immunodeficiency virus (SIV) gp130 oligomers protect rhesus macaques (Macaca mulatta) against the infection with SIVmac32H grown on T-cells or derived ex vivo."
01/01/1993 - "Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection."
12/21/2006 - "Both the tenofovir-treated and untreated macaques infected with SIVmac239Deltanef had antibody responses to SIV gp130 and p27 antigens and SIV-specific CD8+ T cell responses prior to SIVmac055 challenge, but only those animals receiving concurrent treatment with tenofovir resisted infection with SIVmac055. "
09/01/1998 - "In further experiments, we found that resistance to SIVmac251 infection did not correlate with the presence of antibodies to SIV gp130 and p27 antigens and was achieved in the absence of significant neutralizing activity against the primary SIVmac251 challenge stock."

Related Drugs and Biologics

1.	Antigens
2.	Antibodies
3.	Tenofovir (Viread)