HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

interferon gamma receptor

Subscribe to New Research on interferon gamma receptor

distinct from the receptors for interferons alpha and beta; RefSeq NM_000416 (human), NM_010511 (mouse)

Also Known As:

CD119 protein, human; CD119 protein, mouse; CDw119 antigen; CDw119 protein, human; IFN-gamma receptor 1; IFN-gamma-R1 protein, human; IFN-gammaR; IFNGR protein, human; IFNGR1 protein, human; IFNGR2 protein; Ifgr protein, mouse; Ifngr protein, mouse; Ifngr1 protein, mouse; Nktar protein, mouse; cd119 antigen; interferon gamma receptor 1, human; interferon gamma receptor 1, mouse; interferon gamma receptor 2; interferon gamma receptors; receptor, interferon gamma

Networked: 244 relevant articles (8 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Immunologic Receptors: 8
        Cytokine Receptors: 788
        Interferon Receptors: 67
        interferon gamma receptor: 244

Experts

1.	Casanova, Jean-Laurent: 7 articles (09/2010 - 03/2003)
2.	Casanova, J L: 7 articles (10/2001 - 01/2000)
3.	Holland, Steven M: 5 articles (08/2013 - 09/2004)
4.	Speck, Samuel H: 4 articles (01/2015 - 11/2005)
5.	Rojas, Mauricio: 4 articles (08/2010 - 11/2005)
6.	Mora, Ana L: 4 articles (08/2010 - 11/2005)
7.	Chapgier, Ariane: 4 articles (03/2010 - 03/2003)
8.	Kwon, O Jung: 4 articles (11/2007 - 04/2005)
9.	Koh, Won-Jung: 4 articles (11/2007 - 04/2005)
10.	Hwang, Jung Hye: 4 articles (11/2007 - 04/2005)

Related Diseases

1.	Infection 08/01/1997 - "Within the past year, highlights include the mapping of a locus controlling the intensity of infection by Schistosoma mansoni, the demonstration that mutations in the interferon-gamma receptor 1 gene are causative of disseminated infection due to weakly pathogenic mycobacteria, and the identification, in the CCR5 gene, of a deletion which provides high protection against HIV-1 infection. " 08/01/1997 - "IFN-gammaR(-/-) mice cleared an infection with CS100 but were significantly more susceptible than control littermates to infection with C231 or TB521. " 12/01/2000 - "Infection in 129 mice was cleared between days 21 and 28 postchallenge, whereas infection in IFN-gammaR(-) mice was evident in 100% of animals from day 21 onward. " 08/03/1998 - "MCMV-infected IFN-gammaR-/- mice shed preformed infectious MCMV in spleen, peritoneal exudate cells, and salivary gland for up to 6 mo after infection, whereas the majority of congenic control animals cleared chronic productive infection. " 06/01/2006 - "In this study, we demonstrate that a lack of IFN-gamma production or signaling results in increased vulnerability to lethal WNV infection by a subcutaneous route in mice, with a rise in mortality from 30% (wild-type mice) to 90% (IFN-gamma(-/-) or IFN-gammaR(-/-) mice) and a decrease in the average survival time. "
2.	Neoplasms (Cancer) 05/01/2003 - "We show in this study that CD8(+) effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-gammaR. " 03/01/2010 - "A defect in IFN-gammaR increased tumor growth, whereas tumor growth was inhibited in mice that were deficient in both IL-17R and IFN-gammaR compared with wild-type animals. " 10/15/2008 - "We observed that fewer NK cells infiltrated the tumors in IFN-gamma receptor knockout (IFN-gammaR(-/-)) mice compared with wild-type controls that correlated with decreased survival rate. " 01/15/2008 - "These findings suggest that coordinate downregulation of Fas and IFN-gammaR, 2 key components of cancer immunosurveillance system on tumor cells, leads to a more aggressive metastatic phenotype." 01/15/2008 - "Interestingly, disruption of IFN-gammaR function did not alter tumor cell susceptibility to CTL-mediated cytotoxicity, but is linked to enhanced infiltration of endogenous T cells in the tumor microenvironment in vivo. "
3.	Communicable Diseases (Infectious Diseases) 01/25/2002 - "To our knowledge, this is the first report of adenovirus-mediated IFN-gammaR gene transfer being effective in augmenting the biological activity of IFN-gamma, and the strategy employed in the present study will be useful in studying other kinds of cytokine receptors and applications to gene therapy for cancer and infectious diseases."
4.	Hypersensitivity (Allergy) 01/01/2005 - "We concluded that CXCL12 plays a central role in the pathogenesis of CIA in IFN-gammaR KO mice by promoting delayed type hypersensitivity against the auto-antigen and by interfering with chemotaxis of CXCR4+ cells to the inflamed joints. " 01/01/2001 - "Similarly, cutaneous delayed-type hypersensitivity, a typical Th1 response, was abolished in the IL-12-/-, mice but increased in the IFN-gammaR-/- mice. " 05/12/2009 - "Here we show that in naive animals spinal microglia express a receptor for the cytokine IFN-gamma (IFN-gammaR) in a cell-type-specific manner and that stimulating this receptor converts microglia into activated cells and produces a long-lasting pain hypersensitivity evoked by innocuous stimuli (tactile allodynia, a hallmark symptom of neuropathic pain). " 08/01/2000 - "Delayed type hypersensitivity-associated cytokines in islet xenotransplantation: limited efficacy of interleukin-2- and tumor necrosis factor-alpha-blockade in interferon-gamma receptor-deficient mice." 10/01/2008 - "We studied the polymorphisms in the interferon (IFN)-gamma (gamma) and IFN-gamma receptor 1 (IFNR1) gene with the aim of clarifying the relationships among these polymorphisms, penicillin allergy and anti-penicillin antibodies. "
5.	Fibrosis (Cirrhosis) 07/01/2008 - "Thus, in the absence of IFN-gammaR signaling, MHV-68 initiates a Th2 immune response, leading to alternative activation of macrophages and induction of fibrosis. " 07/01/2008 - "We show here that by Day 12 postinfection, prior to development of fibrosis in the spleens of IFN-gammaR-/- mice, different subsets of splenic macrophages (Mvarphis) are morphologically activated and enter latently infected germinal centers (GCs). " 05/01/2005 - "Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers." 01/01/2015 - "A small animal model of multi-organ fibrosis, which involves murine gammaherpesvirus (MHV68) infection of interferon gamma receptor deficient (IFNγR-/-) mice, has been utilized to model the association of gammaherpesvirus infections and lung fibrosis. " 07/01/2008 - "Infection of mice deficient in IFN-gammaR signaling (IFN-gammaR-/-) results in a multiple organ fibrosis, in which the spleen is severely affected. "

Related Drugs and Biologics

1.	Interferon-gamma (Interferon, gamma)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Cytokine Receptors (Cytokine Receptor)
4.	Cytokines
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Antibodies
7.	Interleukin-12 (IL 12)
8.	Interferons
9.	adjuvant P40 (P 40)
10.	Interleukin-12 Receptors (Interleukin 12 Receptor)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Investigational Therapies (Experimental Therapy)
3.	Transplants (Transplant)
4.	Hematopoietic Stem Cell Transplantation
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)