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xestospongin B

structure given in first source; isolated from the sponge Xestospongia sp.

Also Known As:

xestospongine B

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - xestospongin B: 5
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - xestospongin B: 5

Experts

1.	Molgó, Jordi: 3 articles (01/2021 - 04/2005)
2.	Ahumada-Castro, Ulises: 1 article (01/2021)
3.	Bustos, Galdo: 1 article (01/2021)
4.	Cruz, Pablo: 1 article (01/2021)
5.	Cárdenas, César: 1 article (01/2021)
6.	Lovy, Alenka: 1 article (01/2021)
7.	Sauma, Daniela: 1 article (01/2021)
8.	Akl, Mohamed R: 1 article (01/2015)
9.	Ayoub, Nehad M: 1 article (01/2015)
10.	Ebrahim, Hassan Y: 1 article (01/2015)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/08/2015 - "This study evaluated the anticancer activity of the known oxaquinolizidine alkaloids araguspongines A, C, K and L, and xestospongin B against breast cancer cells. "
2.	Starvation 07/01/2009 - "Xestospongin B- or starvation-induced autophagy was inhibited by overexpression of the IP(3)R ligand-binding domain, which coimmunoprecipitated with Beclin 1. These results identify IP(3)R as a new regulator of the Beclin 1 complex that may bridge signals converging on the ER and initial phagophore formation." 12/01/2011 - "Moreover, recombinant Beclin 1 sensitized Ins(1,4,5)P3Rs in 45Ca2+-flux assays, indicating a direct regulation of Ins(1,4,5)P3R activity by Beclin 1. Finally, we found that Ins(1,4,5)P3R-mediated Ca2+ signaling was critical for starvation-induced autophagy stimulation, since the Ca2+ chelator BAPTA-AM as well as the Ins(1,4,5)P3R inhibitor xestospongin B abolished the increase in LC3 lipidation and GFP-LC3-puncta formation. "
3.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/11/2021 - "Here, we determine the bioenergetic profile of the T-ALL cell lines CCRF-CEM and Jurkat and evaluate their sensitivity to InsP3R inhibition with the specific inhibitor, Xestospongin B (XeB). "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/11/2021 - "Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells."
5.	Neuroblastoma 04/11/2005 - "It is concluded that xestospongin B is an effective cell-permeant, competitive inhibitor of IP(3) receptors in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells." 04/11/2005 - "Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells." 04/11/2005 - "Xestospongin B, depending on the dose, suppressed bradykinin-induced Ca(2+) signals in neuroblastoma (NG108-15) cells, and also selectively blocked the slow intracellular Ca(2+) signal induced by membrane depolarization with high external K(+) (47 mM) in rat skeletal myotubes. "

Related Drugs and Biologics

1.	Alkaloids
2.	Beclin-1
3.	Ligands
4.	Chelating Agents
5.	Bradykinin
6.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester