A 802715

causes dose-dependent protection against lipopolysaccharide induced lethal shock; counteracts tumor necrosis factor alpha toxicity

Also Known As:

1-(5-hydroxy-5-methyl)hexyl-3-methyl-7-propylxanthine; A 80 2715; A-802715; 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propyl-

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - A 802715: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        A 802715: 2

Related Diseases

1.	Shock 08/01/1992 - "The xanthine derivative A 802715 (1-(5-hydroxy-5-methyl)hexyl-3-methyl-7- propyl-xanthine, Hoechst AG) caused dose-dependent protection against lipopolysaccharide (LPS)-induced lethal shock in mice. "
2.	Acute Lung Injury 09/01/1995 - "Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of pentoxifylline."
3.	Septic Shock (Toxic Shock Syndrome) 08/01/1992 - "It is concluded that A 802715 counteracts TNF alpha toxicity and that the drug bears the potential of therapeutic intervention in septic shock."

Related Drugs and Biologics

1.	Xanthine
2.	Lipopolysaccharides
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Pentoxifylline (Trental)
5.	Endotoxins
6.	1- (5- hydroxy- 5- methylhexyl)- 3- methylxanthine