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pancopride
structure given in first source; a selective 5-HT3 receptor antagonist; effective against anticancer drug-evoked emesis
Also Known As:
LAS 30451; LAS-30451; N-(1-azabicyclo(2.2.2)oct-3-yl)-2-cyclopropylmethoxy-4-amino-5-chlorobenzamide; pancopride, (+-)-isomer
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Benzamides: 115
pancopride: 2
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Benzamides: 115
pancopride: 2
Carboxylic Acids: 973
Carbocyclic Acids
Benzoates: 426
Benzamides: 115
pancopride: 2
Heterocyclic Compounds: 198
Bridged-Ring Heterocyclic Compounds
Heterocyclic Bridged Bicyclo Compounds
pancopride: 2
Related Diseases
1.
Vomiting
11/10/1992 - "
Pancopride ((+-)N-(1-azabicyclo-[2,2,2]-oct-3-yl)-2-cyclopropylmethoxy-4-ami no-5-chlorobenzamide) is a new potent and selective 5-HT3 receptor antagonist, orally and parenterally effective against cytotoxic drug-induced emesis.
"
11/10/1992 - "
Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis.
"
11/10/1992 - "
These results support clinical data, indicating that pancopride will be a useful drug for treating cytostatic-induced emesis in humans.
"
11/10/1992 - "
Pancopride dose dependently inhibited the number of vomiting episodes and delayed the onset of vomiting induced by cisplatin in dogs (ID50 = 3.6 micrograms/kg i.v. and 7.1 micrograms/kg p.o.).
"
11/01/1995 - "
Pancopride (PNC) is a new 5HT3 receptor antagonist which has demonstrated complete protection from nausea and vomiting in 25-73% of patients treated with highly emetogenic chemotherapy.
"
2.
Nausea
11/01/1995 - "
Pancopride (PNC) is a new 5HT3 receptor antagonist which has demonstrated complete protection from nausea and vomiting in 25-73% of patients treated with highly emetogenic chemotherapy.
"
3.
Bradycardia
11/10/1992 - "
In vivo, pancopride antagonized 5-HT-induced bradycardia in anaesthetized rats when administered i.v. 5 min (ID50 = 0.56 microgram/kg) or p.o.
"
Related Drugs and Biologics
1.
5-HT3 Serotonin Receptors (5 HT3 Receptor)
2.
Mechlorethamine (Nitrogen Mustard)
3.
Dacarbazine (DIC)
4.
pancopride
5.
Cytostatic Agents
6.
Dexamethasone (Maxidex)
7.
Cisplatin (Platino)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)