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5- (2,3,5- trichlorophenyl)pyrimidine- 2,4- diamine ethane sulfonate

Also Known As:

BW 1003C87; BW-1003C87; Ethanesulfonic acid, compd. with 5-(2,3,5-trichlorophenyl)-2,4-pyrimidinediamine (1:1)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate: 2

Related Diseases

1.	Seizures (Absence Seizure) 06/01/1993 - "ED50 values against clonic seizures (in mumol/kg at the time of peak anticonvulsant effect) were: phenytoin 30.5 (2 h), diazepam 0.5 (0.5 h), MK 801 0.01 (4 h), D(-)CPPene 1.9 (4 h), CGP 37849 2 (1 h), GYKI 52466 24 (0.25 h), NBQX 40 (0.5 h), ACPC 1053 (0.5 h), BW 1003C87 2.2 (1 h), lamotrigine 4.8 (4 h). "
2.	Ischemia 10/09/1992 - "In anaesthetised rats with microdialysis probes implanted in the cortex and the caudate nucleus ipsilateral to a middle cerebral artery (MCA) occlusion the increase in dialysate glutamate concentration seen in the first 2 h following MCA occlusion is markedly attenuated by the prior administration of BW 1003C87, 20 mg/kg i.v. In rats subjected to 10 min of bilateral common carotid artery occlusion the loss of CA1 pyramidal neurons (assessed 7 days later) is reduced by administration of BW 1003C87 (20 mg/kg i.v., at the time of ischemia and 4 h later). "
3.	Infarction (Infarctions) 10/09/1992 - "The volume of cortex showing infarction 72 h after unilateral MCA occlusion is reduced by treatment with BW 1003C87 (20 mg/kg, i.v., beginning 5 min after occlusion). "
4.	Epilepsy (Aura) 06/01/1993 - "Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat."
5.	Brain Ischemia (Cerebral Ischemia) 10/09/1992 - "BW 1003C87, 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid, has been tested for its in vitro and in vivo effects on glutamate release in rat brain tissue, and for its cerebro-protective action in two rodent models of cerebral ischemia. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Excitatory Amino Acid Antagonists
3.	Dizocilpine Maleate (Dizocilpine)
4.	Dialysis Solutions
5.	Phenytoin (Dilantin)
6.	Ethane
7.	Diazepam (Valium)
8.	Anticonvulsants (Antiepileptic Drugs)
9.	Acids
10.	Lamotrigine (Lamictal)